CAS 2135-17-3 MFCD00056464-Flumethasone 氟米松 TAO{mole}

Flumethasone 氟米松

CAS 2135-17-3 MFCD00056464

化学结构图

SMILES: CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO

化学属性

Mol. Formula	C22H28F2O5
Mol. Weight	410
Solubility	DMSO 82 mg/mL Water <1 mg/mL Ethanol 6 mg/mL

别名和识别编码

Chemical Name	Flumethasone
CAS Number	2135-17-3
Synonym	######## 1,4-PREGNADIEN-6-ALPHA, 9-ALPHA-DIFLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 6A-FLUORO-DEXAMETHASONE 6ALPHA,9ALPHA-DIFLUORO-16ALPHA-METHYLPREDNISOLONE 6a,9a-difluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione 6a,9a-difluoro-16a-methylprednisolone 6Α-氟地塞米松 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 6α,9α-Difluoro-16α-methylprednisolone 6α-Fluorodexamethasone ANIPRIME Anaprime Aniprime FLUCORT FLUMETHASONE Flumethasone Fluorodexamethasone RS-2177 U-10974 flucorticin flumethason fluvet ha-methyl- methagon rs-2177 氟米松; 双氟美松福如迈塔松
MDL Number	MFCD00056464
PubChem Substance ID	16490
EC Number	218-370-9
Chemical Name Translation	氟米松
Wiswesser Line Notation	L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1 FQ G1 LF
Beilstein Registry Number	5645455
LabNetwork Molecule ID	LN01307226
InChI	InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1

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产品应用

A glucocorticoid. An anti-inflammatory.

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P308+P313
P318
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H351 Suspected of causing cancer 怀疑致癌
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害

RTECSTU3832000

Signal word

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes Xn

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

Storage condition 储存温度 2-8℃ 储存温度-20°C 2-8°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - cattle
DOSE                    : 30 ug/kg
SEX/DURATION            : female 31 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   JAVMA4 Journal of the American Veterinary Medical Association.  (American
   Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)  V.48-
   1915-  Volume(issue)/page/year: 160,867,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - cattle
DOSE                    : 20 ug/kg
SEX/DURATION            : female 38 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 28,407,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - cattle
DOSE                    : 20 ug/kg
SEX/DURATION            : female 40 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   THGNBO Theriogenology.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1974-  Volume(issue)/page/year: 20,267,1983

其他信息

Flumethasone是一种糖皮质激素受体激动剂，该复合物结合到核中，造成各种基因激活和抑制。
Flumethasone
MOL 文件:2135-17-3.mol
Sigma Aldrich:2135-17-3(sigmaaldrich)