CAS 4936-47-4 MFCD00057257-5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone 5-[(甲硫基)甲基]-3-[[(5-硝基-2-呋喃基)亚甲基]氨基]-2-恶唑烷酮 TAO{mole}

5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone 5-[(甲硫基)甲基]-3-[[(5-硝基-2-呋喃基)亚甲基]氨基]-2-恶唑烷酮

CAS 4936-47-4 MFCD00057257

化学结构图

SMILES: CSCC1CN(N=Cc2ccc([N+](=O)[O-])o2)C(=O)O1

化学属性

Mol. Formula	C10H11N3O5S
Mol. Weight	285
Density	1.422
Melting Point	176-178
Solubility	Soluble in DMF, ethyl acetate (sparingly), acetone (sparingly), and methanol (sparingly). Insoluble in water.

别名和识别编码

Chemical Name	5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone
CAS Number	4936-47-4
Synonym	5-((Methylthio)methyl)-3-((5-nitrofurfurylidine)amino)-2-oxazolidinone 5-Methylthiomethyl-3-(5-nitrofurfurylideneamino)-2-oxazolidone 5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone, Methylmercadone, Inimur, Macmiror, Magmilor, Omnes, Polmiror, Tydantil 5-methylthiomethyl-3-(5-nitrofurfurylideneamino)-2-oxazolidone Inimur MACMIROR Macmiror Magmilor Methylmercadone Metilmercadon NF 113 NIFURATEL (MACMIROR) Nifuratel Omnes Polmiror SAP 113 Thiodinon Tydantil l'N-(5-Nitro-2-furfurilidene)-3-amino-5-metilmercaptometil-2-ossazolidinone nf113 硝呋太尔
MDL Number	MFCD00057257
EC Number	225-576-2
Beilstein Registry Number	0842878
Chemical Name Translation	5-[(甲硫基)甲基]-3-[[(5-硝基-2-呋喃基)亚甲基]氨基]-2-恶唑烷酮
Wiswesser Line Notation	T5OJ BNW E1UN- AT5NVOTJ E1S1
LabNetwork Molecule ID	LN02220041
PubChem Substance ID	6433427
InChI	InChI=1S/C10H11N3O5S/c1-19-6-8-5-12(10(14)18-8)11-4-7-2-3-9(17-7)13(15)16/h2-4,8H,5-6H2,1H3/b11-4+

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产品应用

An antibacterial, antifungal, and antiprotozoal compound.

安全信息

Signal word Danger

GHS Symbol

WGK Germany3

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Storage condition 储存温度-20°C

RTECSRQ3590000

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHTPBA Chimica Therapeutica.  (Paris, France)  V.1-8, 1965-73.  For
   publisher information, see EJMCA5.  Volume(issue)/page/year: 1,181,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >4500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 19,301,1964

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ng/plate
REFERENCE :
   MIGIA6 Minerva Ginecologia.  (Edizioni Minerva Medica, Casella Postale 491,
   I-10126 Turin, Italy) V.1-    1949-  Volume(issue)/page/year: 31,263,1979

其他信息

主要功效:硝呋太尔是硝基呋喃衍生物，是一种广谱抗菌素，具有广谱抗微生物作用，制霉菌素为多烯类抗真菌药，对滴虫、细菌、白色念珠菌等均具有较强活性，尤其对妇科感染的常见病原体如革兰氏阳性和阴性细菌、滴虫、霉菌、衣原体和支原体都有强的杀灭作用。口服后经胃肠道吸收，大部分通过肾脏排泄，在血、尿、生殖器组织浓度较高，故在泌尿系统中可产生强烈的抗菌作用，其代谢产物仍有抗菌活性，且自尿中排出。口服硝呋太尔吸收迅速，口服200mg后2小时即达血药峰浓度为9.48μg/L。试验证明，本品在动物的急性毒理试验中毒性反应轻微。硝呋太尔适应症包括： 1、细菌性阴道病、滴虫性阴道炎、念珠菌性外阴阴道炎、阴道混合感染。 2、泌尿系统感染。 3、消化道阿米巴病及贾滴虫病。
MOL 文件:4936-47-4.mol
Nifuratel(NF 113, SAP 113) is a broad antibacterial spectrum agent, which is used as an antibacterial, antifungal, and antiprotozoal (Trichomonas).
检测方法:HPLC,NMR