Diaveridine 5-(3,4-二甲氧苄基)-2,4-嘧啶二胺
CAS 5355-16-8 MFCD00057349
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- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Bioactive Small Molecules, Cell Biology,
- {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, Antibiotics, Bioactive Small Molecules, Cell Biology, Chemical Structure, Chromatography, Clinical Standards, D, D-DIF,
- {SNA} Analytical Standards,
- {SNA} Analytical Standar
- {SNA} Analytical Standards, Antibiotics Standards, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecule Alphabetical Index,
相关文献及参考
- Merck 14 ,2993
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352
- P304+P340
- P305+P351+P338
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P319
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P332+P313
- P332+P317
- P337+P313
- P337+P317
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P362+P364
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6028 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 20(suppl 1),191,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3679 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 20(suppl 1),191,1988
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 5 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 261,149,1991
其他信息
- MOL 文件:5355-16-8.mol
- 方法二:由3-甲氧基-4-羟基苯甲醛(香草醛)经甲基化、缩合、加成、环合而得。
- 用途二:有抗菌作用,对磺胺类药物和抗菌素有明显的增效作用,内服吸收较少,在肠胃内浓度高,适用于肠道感染,本品与磺胺喹啉或磺胺对甲氧嘧啶混合制成预混剂可添加于饲料内,也可制成片剂膏剂,用于治疗家禽细菌感染,对抗球菌病和畜禽肠道感染也有良好的防治作用。
- 用途一:有抗菌作用,对磺胺类药物和抗生素有明显的增效作用
- MSDS 信息:2,4-Diamino-5-(3,4-dimethoxybenzyl)pyrimidine(5355-16-8).msds
- 用途三:兽药磺胺增效剂,用于防治家禽细菌感染。也是抗球虫药,与磺胺喹噁啉合用,治疗家禽球虫病。
- 上游原料:苯甲醛 --> 香兰素 --> 苯甲醚 --> 活性炭(脱色) --> 硝酸胍 --> 藜芦醛 --> 甲醇钠溶液
- Sigma Aldrich:5355-16-8(sigmaaldrich)
- 方法一:以香草醛为原料,先用硫酸二甲酯甲基化得3,4-二甲氧基苯醛(藜芦醛),然后与甲氧基丙腈缩合生成3',4'-二甲氧基-2-氰基-3-甲氧基丙烯,再经加成,最后与硝酸胍环合而得。 香草醛溶于氢氧化钠溶液于60-80℃滴加硫酸二甲酯,并于碱性条件(HP7-9)下回流反应3h。反应液稍冷后用甲苯萃取,萃取液回收溶剂后得藜芦醛。在甲醇与甲醇钠溶液中,藜芦醛与甲氧基丙腈于65-70℃下回流反应5h。加水冷却后结晶,过滤、干燥得3',4'-二甲氧基-2-氰基-3-甲氧基丙烯。 上述缩合物在甲醇、甲醇钠中与硝酸胍于75℃下搅拌反应2h,然后于95℃下继续反应5h。冷却后析出结晶,过滤得二甲氧苄氨嘧啶粗品。粗品经乙酸重结晶、活性炭脱色(95℃,1h),氨水碱析、分离、干燥得成品。