CAS 3737-09-5 MFCD00057366-Disopyramide 4-(二异丙基氨基)-2-苯基-2-(2-吡啶基)丁酰胺 TAO{mole}

Disopyramide 4-(二异丙基氨基)-2-苯基-2-(2-吡啶基)丁酰胺

CAS 3737-09-5 MFCD00057366

化学结构图

SMILES: CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C

化学属性

Mol. Formula	C21H29N3O
Mol. Weight	339.48
Melting Point	94.5-950C

别名和识别编码

Chemical Name	Disopyramide
CAS Number	3737-09-5
MDL Number	MFCD00057366
Synonym	ALPHA-DIISOPROPYLAMINOETHYL-ALPHA-PHENYLPYRIDINE-2-ACETAMIDE Isorythm Lispine 4-Diisopropylamino-2-phenyl-2-(2-pyridyl)-butyramide 4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide ALPHA-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL]-ALPHA-PHENYL-2-PYRIDINE ACETAMIDE SC 7031 达舒平 Searle 703 H. 3292 alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamid gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide sc7031 H 3292 DISOPYRAMIDE Dicorantil 异脉定 searle703 2-Pyridineacetamide, alpha-[2-[bis(1-methylethyl)amino]ethyl]-alpha-phenyl- 丙吡胺 alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide 2-Pyridineacetamide, alpha-[2-(diisopropylamino)ethyl]-alpha-phenyl- h3292 Ritmodan 双异丙吡胺 Disopyramide
PubChem Substance ID	3114
EC Number	223-110-2
Chemical Name Translation	4-(二异丙基氨基)-2-苯基-2-(2-吡啶基)丁酰胺
Wiswesser Line Notation	T6NJ BXR&VZ2NY1&1&Y1&1
LabNetwork Molecule ID	LN01308936
Reaxys-RN	492056
Merck Number	3360
Beilstein Registry Number	22(5)14,172
InChI	InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)

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安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P301+P312+P330
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害

Signal word Warning

RTECSUR8432000

Hazard Codes Xn

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Storage condition 2-8°C

Risk Statements

R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 333 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 38,1398,1988

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 136,114,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 39100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
   V.8-43    1953-88 For pub

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 42200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
   V.8-43    1953-88 For publisher information, see FRMCE8
   Volume(issue

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 420 mg/kg
SEX/DURATION            : female 9-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 5,1641,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11200 mg/kg
SEX/DURATION            : male 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 5,1628,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11200 mg/kg
SEX/DURATION            : female 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 5,1628,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1260 mg/kg
SEX/DURATION            : female 7-13 day(s) a

其他信息

用途一:心脏病类药。抗心律失常，适用于室上性室心早搏、各类心动过速房颤等。
Sigma Aldrich:3737-09-5(sigmaaldrich)
方法一:2-溴吡啶与苄腈、N,N-二异丙基氯乙胺缩合、水解，再与磷酸成盐即得到治疗心律失常药双异丙吡胺。
MOL 文件:3737-09-5.mol
上游原料:氰化苄 --> 2-氯丙烷 --> 2-溴吡啶