CAS 1812-30-2 MFCD00057902-Bromazepam 溴西泮 TAO{mole}

Bromazepam 溴西泮

CAS 1812-30-2 MFCD00057902

化学结构图

SMILES: O=C1CN=C(c2ccccn2)c2cc(Br)ccc2N1

化学属性

Mol. Formula	C14 H10 Br N3 O
Mol. Weight	316.15
Flash Point	11 °C

别名和识别编码

Chemical Name	Bromazepam
CAS Number	1812-30-2
Synonym	1,3-Dihydro-7-bromo-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one 1,3-dihydro-7-bromo-5-(2-pyridyl)-2h-4-benzodiazepin-2-one 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-bromo-5-(2-pyridyl)- 2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridinyl)- 2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridyl)- 7-BROMO-5-[2-PYRIDYL]-3H-1,4-BENZODIAXEPIN-2[1H]-ONE 7-Bromo-1,3-dihydro-5-(2-pyridinyl)-2H-1,4-benzodiazepin-2-one 7-Bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzdiazepin-2-one 7-Bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one 7-Bromo-5-(2-pyridinyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiaxepin-2(1H)-one 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiazepin-2(1H)-one 7-Bromo-5-(pyridin-2-yl)-1H-benz 7-Bromo-5-(pyridin-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one
MDL Number	MFCD00057902
PubChem Substance ID	2441
EC Number	200-659-6
Chemical Name Translation	溴西泮
Wiswesser Line Notation	T67 GMV JN IHJ CE K- BT6NJ
Beilstein Registry Number	0618645
InChI	InChI=1S/C14H10BrN3O/c15-9-4-5-11-10(7-9)14(17-8-13(19)18-11)12-3-1-2-6-16-12/h1-7H,8H2,(H,18,19)

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产品应用

Controlled substance (depressant). Anxiolytic.

安全信息

RTECSDE9800000

GHS Symbol

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P312
P301+P317
P302+P352
P304+P340
P305+P351+P338
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Warning Danger

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H311 Toxic in contact with skin 皮肤接触中毒
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H331 Toxic if inhaled 吸入中毒
H335 May cause respiratory irritation 可能导致呼吸道刺激
H370 Causes damage to organs 导致器官损伤

Hazard Codes Xn Xn,T,F

WGK Germany1

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R11 Highly flammable 非常易燃
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险

Packing GroupIII

Hazard Class6.1(b)

Storage condition 2-8°C N/A No Data Available

UN Number 3249

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6870 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 17,115,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1660 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Ya

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,1048,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 879 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 17,115,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1690 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Re

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 150 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 189,319,1987

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 150 mg/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,23,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 150 mg/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,23,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 210 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
                          female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - mus

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 110 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 26,111,1983

TYPE OF TEST            : TDLo - Lowest pu

TYPE OF TEST            : TDLo - Lowest publi

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 875 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 7,2422,1973

TYPE OF TEST            :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 130 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mort

其他信息

Sigma Aldrich:1812-30-2(sigmaaldrich)
MOL 文件:1812-30-2.mol
储运特性:库房通风低温干燥
急性毒性:口服-大鼠 LD50: 1950 毫克/公斤; 口服-小鼠 LD50: 879 毫克/公斤
毒性分级:中毒
灭火剂:水,泡沫,沙土,二氧化碳,干粉
可燃性危险特性:热分解排出有毒氮氧化物和溴化氢烟雾
刺激数据:皮肤-人 3 毫克/3天(断续) 中度
类别:有毒物品