CAS 1172-18-5 MFCD00058189-Flurazepam dihydrochloride 氟西泮二盐酸盐 TAO{mole}

Flurazepam dihydrochloride 氟西泮二盐酸盐

CAS 1172-18-5 MFCD00058189

化学结构图

SMILES:

化学属性

Mol. Formula	C21H23ClFN3O · 2HCl
Mol. Weight	460.80
Solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <;6 mg/mL
Appearance	solid

别名和识别编码

Chemical Name	Flurazepam dihydrochloride
CAS Number	1172-18-5
Synonym	盐酸氟安定 2h-1,4-benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluoropheny 7-CHLORO-1-(DIETHYLAMINO)ETHYL-5-(2-FLUOROPHENYL)-3H-1,4-BENZODIAZEPIN-2(1H)-ONE DIHYDROCHLORIDE 氟西泮盐酸盐氟西泮二盐酸盐 ######## Somlan dalmate dalmadorm NSC-78559 dalmadormhydrochloride Dalmane ro5-6901 ID 480 FLURAZEPAM DIHYDROCHLORIDE 7-氯-1-(二乙氨基)乙基-5-(2-氟苯基)-3H-1,4-苯并二氮杂-2(1H)-酮二盐酸盐 felison id480dihydrochloride Dalmate insumin Flurazepam dihydrochloride Dormodor benozil Dalmadorm hydrochloride nsc-78559 Lunipax Benozil Ro 5-6901 盐酸氟西洋 Insumin dormodor FLURAZEPAM HYDROCHLORIDE FLURAZEPAM HCL lunipax id480 dalmane Dalmadorm ID 480 dihydrochloride 1,3-dihydro-l)dihydrochloride 盐酸氟西泮 Felison FLURAZEPAM DIHCL Flurazepam hydrochloride
MDL Number	MFCD00058189
EC Number	214-630-0
PubChem Substance ID	24894741
Chemical Name Translation	氟西泮二盐酸盐
Wiswesser Line Notation	T67 GNV JN IHJ CG G2N2&2 KR BF &GH 2

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产品应用

Flurazepam is used as an sedative, hypnotic.

安全信息

GHS Symbol

Precautionary statements

P301+P310
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H302 Harmful if swallowed 吞食有害
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官

WGK Germany3

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S1/2 None 上锁保管并避免儿童触及；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Hazard Codes Xn

Risk Statements

R22 Harmful if swallowed 吞咽有害
R33 Danger of cumulative effects 有累积作用的危险

Packing GroupIII

Hazard Class6.1(b)

Storage condition 2-8°C

UN Number 3249

RTECSDF0875000

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 568 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 178,216,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 186 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 26,741,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 596 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 152 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 26,741,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral

其他信息

Sigma Aldrich:1172-18-5(sigmaaldrich)
MOL 文件:1172-18-5.mol
color:light yellow
用途一:适用于各种抑郁性精神障碍。