Ribavirin 利巴韦林
CAS 36791-04-5 MFCD00058564
化学结构图
SMILES: NC(=O)C1N=[14CH]N(N=1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
化学属性
| Mol. Formula | C8H12N4O5 |
|---|---|
| Mol. Weight | 244 |
| Density | 2.08 |
| Melting Point | 176°C |
| Solubility | Soluble in water (20 mg/ml), DMSO (49 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and alcohol (slightly). |
别名和识别编码
| Chemical Name | Ribavirin |
|---|---|
| CAS Number | 36791-04-5 |
| Alfabeta Name | RIBAVIRIN |
| MDL Number | MFCD00058564 |
| Synonym | 1-(-D-Ribofuranosyl)-1,2,4-triazole-3-carboxamide 1-(β-D-Ribofuranosyl)-1,2,4-triazole-3-carboxamide 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide Icn-1229 RTCA Ribamidyl Ribavirin Virazole 三氮唑核苷;1-β-D-呋喃核糖-1,2,4-三氮唑-3-羟酰胺;病毒唑 利巴韦林 |
| PubChem Substance ID | 87559671 |
| EC Number | 250-023-7 |
| Beilstein Registry Number | 892462 |
| Reaxys-RN | 892462 |
| Merck Number | 8198 |
| Chemical Name Translation | 利巴韦林 |
| Wiswesser Line Notation | T5OTJ B1Q CQ DQ E- AT5NN DNJ CVZ |
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分类
- {SA} AIDS and Viral Research Reagents, Analytical Standards, Analytical/Chromatography, Antibiotics,
- {Chemicalbook} 生物化学品: 核酸类: 核苷酸及其衍生物
- {SNA} AIDS and Viral Research Reagents, Antibiotics A to Z, Antibiotics N-S, Antiviral, Chemical Structure Class, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
产品应用
- A broad spectrum antiviral nucleoside and inhibitor of inosine monophosphate dehydrogenase.
相关文献及参考
- Merck: 14,8198
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P305+P351+P338
- P308+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H303 May be harmfully swallowed 吞食可能有害
- S22 Do not breathe dust 不要吸入粉尘；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2700 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes Blood - hemorrhage REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,1150,1972
TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 40 mg/kg/24H (Continuous) REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,213,1989
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 600 mg/kg/3D (Continuous) REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,213,1989
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - rabbit Kidney DOSE/DURATION : 4900 ug/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 38,1771,1989
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - rabbit Kidney DOSE/DURATION : 1700 ug/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 38,1771,1989
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 4800 ug/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 38,1771,1989
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 8600 ug/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Perg
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - hamster DOSE : 2500 ug/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 17,93,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 37500 ug/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 17,93,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 9 gm/kg SEX/DURATION : male 60 day(s) pre-mating TOXIC EFFECTS : Reprodu
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - hamster DOSE : 5 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalit
其他信息
- Ribavirin is a non-interferon-inducing, broad spectrum antiviral nucleoside. Ribavirin is reported to be active against RSV, HIV, HCV, and other infectious agents. The compound’s metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.
