CAS 58-94-6 MFCD00058576-2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide 6-氯-2H-1,2,4-苯并噻二嗪-7-磺酰胺-1,1-二氧化物 TAO{mole}

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide 6-氯-2H-1,2,4-苯并噻二嗪-7-磺酰胺-1,1-二氧化物

CAS 58-94-6 MFCD00058576

化学结构图

SMILES: NS(=O)(=O)c1cc2c(cc1Cl)N=CNS2(=O)=O

化学属性

Mol. Formula	C7H6ClN3O4S2
Mol. Weight	295.72
Melting Point	342-343 ºC
Solubility	<0.1 G/100 ML AT 19.5 ºC

别名和识别编码

Chemical Name	2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
CAS Number	58-94-6
Synonym	2-chloro-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-,1,1-dioxide 6-CHLORO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE 6-Chloro-2H-1,2,4-benzothiadiazine- 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide 6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1 6-Chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide 6-Chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide 6-chloro-7-sulfamoyl-2h-1,2,4-benzo 6-氯-2H-1,2,4-苯并噻二嗪-7-磺酰胺-1,1-二氧化物 Aldoclor Alurene CHLOROTHIAZIDE Chloriazid Chlorosal Chlorothiazid Chlorothiazide Chlorthiazide Chlortiazid Chlorurit Chlotride Chlrosal Clotride Diupres Diuresal Diuril Diurilix Diurite Diutrid Flumen Minzil Neo-Dema Neo-dema SK-Chlorothiazide Salisan Salunil Saluretil Saluric Thiazide Urinex Warduzide Yadalan chlorothiazide (INN) component of Aldoclor component of Diupres 氯噻嗪
MDL Number	MFCD00058576
PubChem Substance ID	2720
EC Number	200-404-9
Chemical Name Translation	6-氯-2H-1,2,4-苯并噻二嗪-7-磺酰胺-1,1-二氧化物
Merck Number	2168
Wiswesser Line Notation	T66 BSWM ENJ HG ISZW
LabNetwork Molecule ID	LN00196876
InChI	InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

Diuretic; antihypertensive.

安全信息

RTECSDK9450000

WGK Germany2

GHS Symbol

Precautionary statements

P342+P311
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Signal word Danger

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

Hazard Codes Xn

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R42/43

Storage condition 2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1386 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,77,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 134,273,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   1,333,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghe

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12450 mg/kg
SEX/DURATION            : female 8-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   JCINAO Journal of Clinical Investigation.  (Rockefeller Univ. Press, 1230
   York Ave., New York, NY 10021)  V.1-    1924-  Volume(issue)/page/year:
   41,710,1962

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3520 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   ANREAK Anatomical Record.  (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
   10003)  V.1-    1906/08-  Volume(issue)/page/year: 193,174,1979

其他信息

Sigma Aldrich:58-94-6(sigmaaldrich)
TCI Shanghai:氯噻嗪 Chlorothiazide,>;95.0%(T)(58-94-6)
图谱信息:氯噻嗪(58-94-6)质谱(MS) 氯噻嗪(58-94-6)红外图谱(IR1) 氯噻嗪(58-94-6)红外图谱(IR2)
用途一:利尿药。
MSDS 信息:Chlorothiazide(58-94-6).msds
MOL 文件:58-94-6.mol