CAS 1508-75-4 MFCD00058580-N-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridin-4-Ylmethyl)Propanamide N-乙基-3-羟基-2-苯基-N-(吡啶-4-基甲基)丙酰胺 TAO{mole}

N-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridin-4-Ylmethyl)Propanamide N-乙基-3-羟基-2-苯基-N-(吡啶-4-基甲基)丙酰胺

CAS 1508-75-4 MFCD00058580

化学结构图

SMILES: CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1

化学属性

Mol. Formula	C17H20N2O2
Mol. Weight	284
TSCA	No
Melting Point	97-100
Solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclode?xtrin: soluble4.3 mg/mL ethanol: soluble5.6 mg/mL H2O: insoluble
Appearance	solid

别名和识别编码

Chemical Name	N-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridin-4-Ylmethyl)Propanamide
CAS Number	1508-75-4
Synonym	N-ethyl-N-(4-pyridylmethyl)tropamide n-ethyl-2-phenyl-n-(4-pyrid N-Ethyl-?-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide n-ethyl-alpha-(hydroxymethyl)-n-(4-pyridinylmethyl)-benzeneacetamid N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide, Ro 1-7683 Epitromina TROPICAMIDE Mydriacyl tropi N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamid Tropic acid-N-eth Hydracrylamide, N-ethyl-2-phenyl N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide Ro 1-7683 N-Ethyl-N-(g-picolyl)tropamide N-乙基-N-(4-吡啶甲基)-alpha-羟甲基-苯乙酰胺 N-ETHYL-3-HYDROXY-2-PHENYL-N-PYRIDIN-4-YLMETHYL-PROPIONAMIDE {} {} {u Mydrum Benzeneacetamide, N-ethyl-alpha-(hydroxymethy component of Paremyd N-Ethyl-2-ph
MDL Number	MFCD00058580
PubChem Substance ID	87577232
EC Number	216-140-2
Merck Number	9780
Chemical Name Translation	N-乙基-3-羟基-2-苯基-N-(吡啶-4-基甲基)丙酰胺
Reaxys-RN	285563
Beilstein Registry Number	285563
LabNetwork Molecule ID	LN00873077

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

M4毒蕈碱型乙酰胆碱受体拮抗剂。

安全信息

GHS Symbol

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338
P301+P312+P330
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。

Hazard statements

H332 Harmful if inhaled 吸入有害
H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害
H335 May cause respiratory irritation 可能导致呼吸道刺激
H319 Causes serious eye irritation 严重刺激眼睛

WGK Germany3

Signal word

Hazard Codes Xn

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R42/43

RTECSCY1487860

Storage condition 储存温度2-8℃ 2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 865 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,760,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 695 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,760,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 872 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,760,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 565 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,760,1990

其他信息

眼科用药:托吡卡胺是一种抗胆碱药，常温下为白色结晶性粉末，无臭，在水中微溶，在乙醇、稀盐酸、稀硫酸和氯仿中易溶，能阻滞乙酰胆碱引起的虹膜括约肌及睫状肌兴奋作用。其0.5%溶液可引起瞳孔散大;1%溶液可引起睫状肌麻痹及瞳孔散大。临床上主要用于治疗滴眼散瞳和调节麻痹。托吡卡胺是托品酸的合成衍生物。具有较低的解离常数，眼内通透性良好，组织扩散力强，可能是其起始迅速，维持时间短的原因。本品0.5%、1%溶液滴眼后20-30分钟内散瞳及调节麻痹作用达高峰。随后作用逐渐降低，调节麻痹（残余的）２～６小时。散瞳（残余的）约7小时。托吡卡胺是类似阿托品的药物，故可使闭角型青光眼眼压急剧升高，也可能激发未被诊断的闭角型青光眼。托吡卡胺滴眼液的睫状肌调节麻痹作用强度与剂量密切相关，其0.25%、0.5%、0.75%和1%四种浓度均有调节麻痹作用。滴眼后，最大残余调节度数分别为0.25%3.17屈光度、1%1.30屈光度。残余调节度数能保持在2.0屈光度或以下者，0.75%和1%溶液可维持40分钟，0.5%约为15分钟。1%溶液一滴滴眼后隔5~25分钟再滴第二次，能获得更满意的睫状肌麻痹作用约20~30分钟。经2~6小时能阅读书报，调节功能于6小时内恢复至滴药前水平。
TCI Shanghai:托品酰胺 Tropicamide,>;99.0%(LC)(T)(1508-75-4)
托吡卡胺价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 T1470 托品酰胺 Tropicamide 10G 2010元
用途一:抗胆碱药，散瞳药。
MSDS 信息:N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide(1508-75-4).msds
color:white
MOL 文件:1508-75-4.mol
Sigma Aldrich:1508-75-4(sigmaaldrich)