CAS 34552-83-5 MFCD00058581-Loperamide Hcl 盐酸洛哌丁胺 TAO{mole}

Loperamide Hcl 盐酸洛哌丁胺

CAS 34552-83-5 MFCD00058581

化学结构图

SMILES: Cl.[2H]C([2H])([2H])N(C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1C=CC=CC=1)C1C=CC=CC=1)C([2H])([2H])[2H]

化学属性

Mol. Formula	C29H33ClN2O2.HCl
Mol. Weight	513.50
TSCA	No
Melting Point	223
Boiling Point	223

别名和识别编码

Chemical Name	Loperamide Hcl
Synonym	Imosec Imodium BLOX Fortasec 4-(对-氯苯基)-4-羟基-N,N-二甲基-α,α-二苯基-1-哌啶丁酰胺盐酸盐 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide hydrochloride R 18553 4-(4-(p-Chlorophenyl)-4-hydroxy-1-piperidyl)-N,N-dimethyl-2,2-diphenylbutyramide HCl Suprasec BREK Loperamide hydrochloride Lopemin Loperyl PJ185 Dissenten 洛哌丁胺盐酸盐 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidine butyramide HCl Tebloc 4-(对-氯苯基)-4-羟基-N,N-二甲基-α,α-二苯基-1-哌啶丁酰胺盐酸盐 Lopemid
MDL Number	MFCD00058581
PubChem Substance ID	87572105
EC Number	252-082-4
CAS Number	34552-83-5
Merck Number	5571
Reaxys-RN	4087090
Chemical Name Translation	盐酸洛哌丁胺
Beilstein Registry Number	4087090
Wiswesser Line Notation	T6NTJ A2XR&R&VN1&1 DQ DR DG &GH

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P310
P301+P310+P330
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H301 Toxic if swallowed 吞食有毒

RTECSTM4960000

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Safety Statements

S20 When using do not eat or drink 使用时，不得进食，饮水；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；

Hazard Codes 6.1 T

Risk Statements

R25 Toxic if swallowed 吞咽有毒

Packing GroupIII

UN Number 2811

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 41500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 12,1204,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7490 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 5,2419,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Gastrointestinal - nausea or vomiting
   Gastrointestinal - decreased motility or constipation
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 5,2419,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12640 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   YAC

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 580 mg/kg
SEX/DURATION            : female 15-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,1645,1974

Hazard Class6.1