CAS 1484-85-1 MFCD00060509-1,3-Benzodioxole-5-ethanamine 3,4-亚甲二氧基苯乙胺 TAO{mole}

1,3-Benzodioxole-5-ethanamine 3,4-亚甲二氧基苯乙胺

CAS 1484-85-1 MFCD00060509

化学结构图

SMILES: NCCc1ccc2c(c1)OCO2

化学属性

Mol. Formula	C9H11NO2
Mol. Weight	165
Density	1.422

别名和识别编码

Chemical Name	3,4-Methylenedioxyphenethylamine
CAS Number	1484-85-1
Alfabeta Name	METHYLENEDIOXYPHENETHYLAMINE 34-,
MDL Number	MFCD00060509
Synonym	1,3-BENZODIOXOLE-5-ETHANAMINE 1,3-BENZODIOXOLE-5-ETHYLAMINE 1,3-Benzodioxole-5-ethanamine 2-(3',4'-METHYLENEDIOXY-PHENYL)ETHYLAMINE 2-(3,4-(METHYLENDIOXY)PHENYL)ETHYLAMINE 2-(3,4-METHYLENEDIOXYPHENYL)ETHYLAMINE(HOMOPIPERONYLAMINE) 2-(3,4-Methylenedioxyphenyl)Et 2-(3,4-亚甲二氧苯基)乙胺 3,4-(METHYLENEDIOXYPHENYL)ETHYLAMINE 3,4-(METHYLENEDIOXYPHENYL)ETHYLAMINE 95% 3,4-MDE 3,4-METHYLENEDIOXYPHENETHYLAMINE 3,4-Methylenedioxyphenethylamine 3,4-methylenedioxy-phenethylamin 3,4-methylenedioxyphenethylamine 3,4-亚甲二氧苯乙胺 5-(2-Aminoethyl)benzodioxole AURORA KA-7750 DL-MDEA HCl of 3,4-methylenedioxyphenethylamine HOMOPIPERONYLAMINE Homopiperonylamine ,97% Homopiperonylamine=
EC Number	250-023-7
Beilstein Registry Number	0383838
Chemical Name Translation	3,4-亚甲二氧基苯乙胺
InChIKey	RRIRDPSOCUCGBV-UHFFFAOYSA-N
Wiswesser Line Notation	T56 BO DO CHJ G2Z
PubChem Substance ID	73874
LabNetwork Molecule ID	LN00173233
InChI	InChI=1S/C9H11NO2/c10-4-3-7-1-2-8-9(5-7)12-6-11-8/h1-2,5H,3-4,6,10H2

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产品应用

A metabolite of Dopamine analogs

安全信息

Warnings IRRITANT

Signal word Danger Warning

GHS Symbol

WGK Germany3

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P330+P331
P302+P352
P302+P361+P354
P304+P340
P305+P351+P338
P305+P354+P338
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P316
P317
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P313
P332+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

RTECSSH9670000

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JPHYA7 Journal of Physiology.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.1-    1878-  Volume(issue)/page/year: 76,224,1932

Hazard statements

H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H315 Causes skin irritation 会刺激皮肤
H318 Causes serious eye damage 严重伤害眼睛
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Hazard Codes Xi

其他信息

上游原料:4-氯苯甲醛 --> 乙醇溶液 --> 1-氨基乙醇 --> 1,3-苯并二氧杂环戊烯-5-乙腈 --> 利血平 --> 镍触媒 --> 胡椒乙胺
MOL 文件:1484-85-1.mol
用途一:该品是医药黄连素和多马胺的中间体。
方法一:由胡椒乙腈或胡椒乙叉亚胺经催化加氢制得。将胡椒乙太亚胺、乙醇、镍触媒如入高压釜。用氮置换釜内空气后通入氨气，再通氢。控制压力3-4MPa、温度95-100℃，氢化反应进行至不再吸氢时算起，继续保温、保持氢压30min。冷却至30℃，降压静置，利用釜内余压出料过滤，除去镍触媒（浸入乙醇套用）。滤液先在常压蒸馏回收氨乙醇溶液，再进行减压蒸馏，收集110-140℃（1.33kPa）馏分，得胡椒乙胺。收率80%。采用胡椒乙腈生产时，工艺过程相仿，温度为80-85℃，压力为1MPa左右。得到含量为92-94%的胡椒乙胺。原料消耗定额：胡椒乙腈1050kg/t、兰尼镍23.4kg/t、氢70kg/t、乙醇（99%）982kg/t。