Triphosgene 三光气溶液
CAS 32315-10-9 MFCD00062848
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {uni_hamburg} no charge; carbonate; 1fragment
- {SNA} Chemical Synthesis, Coupling, Greener Alternatives and Technologies, Greener Alternatives: Reagents, Phosgene Derivatives, Phosgene Generation Kit, Synthetic Reagents
- {SNA} Chemical Synthesis, Coupling, Phosgene Derivatives, Synthetic Reagents
- Building Blocks, Carbonates, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
产品应用
- ⑴ 医药合成:用于氯甲酸酯、异氰酸酯、聚碳酸酯、酰氯等精细化学品及阿洛西林、美洛西林、派拉西林及依那普利、降压等药物的合成。是生产抗生素类及其它药物的重要中间体。
- ⑵ 农药制造:用于制造氨基甲酸酯类农药、脲类除草剂、合成除草剂、杀虫剂。
- ⑶ 高分子材料合成:是合成聚氨酯类泡沫塑料的重要原料。
相关文献及参考
- Merck: 14,10355
- Trap for titanocycle intermediates in the bicyclization of enynes using the titanocene dichloride (Bis(cyclopentadienyl)titanium dichloride, A11456) - Mg metal system: J. Org. Chem., 63, 9285 (1998):
- In combination with triethylamine, dehydrates formamides to isocyanides, and carboxylic acids to their anhydrides: J. Org. Chem., 58, 1646 (1993); 59, 2913 (1994).
- Merck: 14,10355 Beilstein:3(4)33
- Ferrari, B., et al.: Bioorg. Med. Chem. Lett., 4, 45
- Convenient crystalline alternative to phosgene in many reactions. See also Trichloromethyl chloroformate, A17444. Possible applications include conversion of amines to isocyanates, diols to carbonates, acids to acyl halides, etc.: Angew. Chem. Int. Ed., 26, 894 (1987). For a brief review, see: J. Prakt. Chem./ Chem. Ztg., 337, 516 (1995); for a comprehensive review: Synthesis, 553 (1996).
- In combination with triphenylphosphine, is a mild reagent for the conversions of alcohols to alkyl chlorides: Synth. Commun., 23, 711 (1993), epoxides to vicinal dichlorides: Synth. Commun., 24, 1715 (1994), and acids to acyl chlorides: Tetrahedron Lett., 38, 6489 (1997).
- Short: III/10a
- In combination with Dimethyl sulfoxide, A13280, has been used for the low-temperature Swern-type oxidation of alcohols to aldehydes: J. Org. Chem., 56, 5948 (1991); 58, 1646 (1993); Org. Prep. Proced. Int., 24, 363 (1992). Compare Oxalyl chloride, A18012.
安全信息
GHS Symbol
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H330 Fatal if inhaled 吸入致命
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P330+P331
- P303+P361+P353+P310+P363
- P304+P340+P310
- P305+P351+P338
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S20 When using do not eat or drink 使用时,不得进食,饮水;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S4 Keep away from living quarters 远离生活区;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S7/8 Keep container tightly closed and dry 保存在严格密闭容器中,保持干燥;
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
- R23 Toxic by inhalation 吸入有毒
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
- R26 Very toxic by inhalation 吸入极毒
- R29 Contact with water liberates toxic gas. 遇水释放出有毒气体
- R34 Causes burns 会导致灼伤
其他信息
- 有类似光气味,溶于乙醇、苯、乙醚、氯仿及二氯甲烷等有机溶剂。遇热水及氢氧化碱则分解,遇冷水基本无作用。实际上不溶于水,可能形成光气,二氯甲烷中溶解度:588 g/L CH2Cl2 (20°C)。