Betamethasone, 97% 倍他米松
CAS 378-44-9 MFCD00062969
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专业采购外包团队在线服务
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分类
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards A - B,
- {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia Metrological Institutes Standards, 分析/色谱
- {SNA} Analytical Standards,
- {
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, B, BA - BH, Bioactive Small Molecules, 细胞生物学
- {SNA} B, Bioactive Small Molecule Alphabetical Index, Corticosteroid,
产品应用
- 校准仪器和装置;评价方法;工作标准;质量保证/质量控制
相关文献及参考
- [2]. Xie W, et, al. Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy. Ann Clin Lab Sci. Winter 2006;36(1):39-46.
- [3]. Kubin ME, et, al. Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα - IL-23 - IL-17 Axis. Acta Derm Venereol. 2017 Apr 6;97(4):449-455.
- [4]. Hofmann TH, et, al. Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441(3):441-6.
- Beil. 8 ,IV,3501
- Corp MSDS 1 (1), 409:B / FT-IR 2 (3), 4234:B / RegBook 1 (2), 2863:M / Sax 6 , 426 / Sigma FT-IR 1 (1), 1200:D / Structure Index 1 , 458:B:8
- Cruz-Monteagudo, M., et al.: Eur. J. Med. Chem., 40, 1030 (2005),
- Ferrante, M.G., et al.: Anal. Profiles Drug Subs., 6, 43 (1977),
- Li, A., et al.
安全信息
- H302+H312+H332
- H330 Fatal if inhaled 吸入致命
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P312+P330
- P302+P350
- P302+P352+P312+P362+P364
- P304+P340
- P304+P340+P312
- P305+P351+P338
- P308+P313
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
- P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
GHS Symbol
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R48/20/21
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,2117,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 1200 ug/kg SEX/DURATION : female 18-20 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo REFERENCE : PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 33,5,1993
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 150 ug/kg SEX/DURATION : female 16-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - biochemical and metabolic REFERENCE : JPEMAO Journal of Perinatal Medicine. (Walter de Gruyter, Inc., 200 Saw Mill River Rd., Hawthorne, NY 10532) V.1- 1973- Volume(issue)/page/year: 22,319,1993
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 2 mg/kg SEX/DURATION : female 18-19 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects REFERENCE : DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 18,14,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Primate - monkey DOSE : 600 ug/kg SEX/DURATION : female 20 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830
其他信息
- MOL 文件:378-44-9.mol
- Sigma Aldrich:378-44-9(sigmaaldrich)
- 图谱信息:倍他米松(378-44-9)核磁图( 13 CNMR) 倍他米松(378-44-9)质谱(MS) 倍他米松(378-44-9)红外图谱(IR1) 倍他米松(378-44-9)红外图谱(IR2)
- 毒性分级:中毒
- 激素类药物:倍他米松又称培他美松、贝皮质醇、贝氟美松、培氟美松,属于肾上腺皮质激素类药物,为地塞米松的同分异构体,作用与泼尼松龙和地塞米松相同,具有抗炎、抗风湿、抗过敏和抑制免疫等多种药理作用,抗炎作用较地塞米松、曲安西龙、氢化可的松等均强,可以减轻和防止组织对炎症的反应,消除局部非感染性炎症引起的发热、发红及肿胀,从而减轻炎症的表现,本品0.3mg的抗炎疗效与地塞米松0.75mg、泼尼松5mg或可的松25mg相当。 倍他米松的钠潴留作用为氢化可的松的百倍以上,在原发性肾上腺皮质功能减退症中,可与糖皮质类固醇一起用于替代治疗,防止或抑制细胞中介的免疫反应,延迟性的过敏反应,并减轻原发免疫反应的扩展,适用于低肾素低醛固酮综合征和植物神经病变所致体位性低血压等。 目前倍他米松还用于治疗活动性风湿病、类风湿性关节炎、红斑性狼疮、严重支气管哮喘、严重皮炎、急性白血病、过敏性皮炎、湿疹、神经性皮炎、脂溢性皮炎及瘙痒症和某些感染的综合治疗。 本品禁用于严重的精神病史,活动性十二指肠、胃溃疡,新近胃肠吻合术后,较重的骨质疏松,明显的糖尿病,严重的高血压,未能用抗菌药物控制的病毒、细菌、霉菌感染、血栓性静脉炎、感染性皮肤病,如脓疱病、体癣、股癣等。
- 上游原料:醋酸倍他米松
- 方法一:按美国专利3164618,将醋酸倍他米松于甲醇-氯仿-水的混合物中以盐酸处理,可使其转换为倍他米松。
- 储运特性:通风低温干燥
- 可燃性危险特性:可燃; 燃烧产生有毒氟化物烟雾
- 急性毒性:口服-小鼠 LD50: >;4500 毫克/公斤
- 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
- 类别:有毒物品
- 倍他米松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B1837 倍他米松 Betamethasone 5G 1230元 2014/06/02 B1837 倍他米松 Betamethasone 1G 410元
- 用途一:激素类药。主要用于抗炎及抗过敏。适用于风湿性关节炎及各种皮肤病。倍他米松的作用同地塞米松,其抗炎作用比地塞米松、去炎松、氢化可的松强,副作用少。