CAS 110-16-7 MFCD00063177-Maleic acid 马来酸 TAO{mole}

Maleic acid 马来酸

CAS 110-16-7 MFCD00063177

化学结构图

SMILES: O=C(O)C=CC(=O)O

化学属性

Mol. Formula	C4H4O4
Mol. Weight	116.07
Density	1.59
Melting Point	130-135 °C
Flash Point	127°C
TSCA	Yes
Solubility	溶于水，溶于乙醇、丙酮，微溶于苯。
Boiling Point	275 °C at 760 mmHg
Stability	对湿度敏感

别名和识别编码

Chemical Name	Maleic acid
CAS Number	110-16-7
EC Number	203-742-5
Beilstein Registry Number	605762
MDL Number	MFCD00063177
Synonym	Maleic Acid {LY} Maleic Acid {} {LY} Maleic Acid {} {} {LY} Maleic Acid {} {} {} {LY} Maleic Acid {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid
PubChem Substance ID	444266
Merck Number	5703
Chemical Name Translation	马来酸
Reaxys-RN	605762
Wiswesser Line Notation	QV1U1VQ -C
LabNetwork Molecule ID	LN00238196
InChI	InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-
Canonical SMILES	O=C(O)/C=C\C(O)=O

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产品应用

碱量法分析标准，减缓油及脂肪的酸败，有机合成。

安全信息

Signal word Danger Warning

GHS Symbol

WGK Germany1

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S37 Wear suitable gloves 戴适当手套；

Risk Statements

R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P301+P330+P331
P303+P361+P353
P304+P340
P305+P351+P338
P333+P313
P337+P313
P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
P403+P233
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H335 May cause respiratory irritation 可能导致呼吸道刺激
H318 Causes serious eye damage 严重伤害眼睛
H319 Causes serious eye irritation 严重刺激眼睛
H302+H312
H290 May be corrosive to metals 可能腐蚀金属。
H302 Harmful if swallowed 吞食有害

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSOM9625000

Hazard Codes 9

UN Number 2215 3077

Packing GroupIII

Hazard Class8

Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1560 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 7-4/1970

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >720 mg/m3/1H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 7-4/1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 708 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 7-4/1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   34,1196,1940

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 183,89,1987

其他信息

Alfa Aesar:马来酸,98+% Maleic acid, 98+%(110-16-7)
用途二:用于制备不饱和树脂和松香脂等
Sigma Aldrich:110-16-7(sigmaaldrich)
TCI Shanghai:顺丁烯二酸 Maleic Acid,>;99.0%(T)(110-16-7)
MSDS 信息:马来酸(110-16-7).msds
马来酸价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 LA1459603 顺丁烯二酸 5kg 1002元 2011/08/23 30111328 顺丁烯二酸 500g 32.2元 2011/04/16 M0006 顺丁烯二酸 Maleic Acid 25G 177元
方法一:1.苯氧化法纯苯经预热后，在钒系列催化剂作用下，经空气氧化生成顺丁烯二酸酐（以下简称顺酐），反应温度为360℃，然后经水吸收、浓缩、结晶和干燥得顺酸产品。2.丁烯（烷）氧化法丁烯（烷）在钒系催化剂作用下，经空气氧化生成顺酐，反应温度350-450℃，然后经水吸收生成顺酸，再经浓缩、干燥得成品。3.其他生产方法（1）萘或邻二甲苯氧化生成苯酐时副产顺酸；（2）糠醛氧化法，此法因效益问题不被采用。
用途四:碱量法分析标准，减缓油及脂肪的酸败，有机合成。
约在138℃时分解。溶于冰乙酸、乙醇、丙酮，微溶于乙醚和苯。实际上不溶于四氯化碳，有恶劣的酸气味，味涩。有腐蚀性。水中溶解度:790 g/L (25°C)。
图谱信息:马来酸(110-16-7)质谱(MS) 马来酸(110-16-7)核磁图( 13 CNMR) 马来酸(110-16-7)核磁图( 1 HNMR) 马来酸(110-16-7)红外图谱(IR1)
用途三:主要用于生产农药马拉松、达净松，合成不饱和聚酯树脂、酒石酸、反丁烯二酸、琥珀酸等产品，也用于涂料、食品和印染助剂及渍脂防腐剂等。
上游原料:苯 --> 马来酸酐 --> 1,2-二甲苯 --> 2-糠醛
MOL 文件:110-16-7.mol
Acros Organics:顺丁烯二酸/马来酸 Maleic acid, 99%(110-16-7)
下游产品:富马酸 --> L-天门冬氨酸 --> 丁二酸 --> D-酒石酸 --> 依那普利 --> DL-酒石酸 --> 富马酸二甲酯 --> 马拉硫磷 --> 伊索拉定 --> PBTCA类缓蚀剂 --> DL-天门冬氨酸 --> 克菌丹 --> 聚马来酸 --> 2-膦酸丁烷-1,2,4-三羧酸 --> 马来酸-烯丙醇共聚物 --> 氨氯地平 --> 氟吡汀 --> 马来酸二丁酯 --> 马来酸氯苯那敏 --> DL-苹果酸 --> 反丁烯二腈 --> 1,1'-二膦酸丙酸基膦酸钠 --> 3,4,5-三甲氧基苯甲酸 (2-二甲胺基-2-苯基)丁酯马来酸盐 --> DL-苹果酸 --> 5-溴-2-甲氧基肉桂酸 --> 巯基丁二酸 --> 泊拉得可
外观性质:无色晶体, 有特臭。
用途一:用于制药、树脂合成，也用作油和油脂的防腐剂