3,6-Diamino-10-methylacridinium chloride-3,6-acridinediamine mixt 吖啶黄

CAS 8048-52-0 MFCD00064307

化学结构图

8048-52-0
SMILES: C[n+]1c2cc(N)ccc2cc2ccc(N)cc21.Nc1ccc2cc3ccc(N)cc3nc2c1.[Cl-]

化学属性

Mol. FormulaC14
Mol. Weight469
Melting Point179-181
Density1.296
SolubilitySoluble in water (330 mg/ml), ethanol, and alcohol (1:40). Insoluble in ether, and chloroform

别名和识别编码

Chemical Name3,6-Diamino-10-methylacridinium chloride-3,6-acridinediamine mixt
Synonym 2,8-Diamino-10-Methylacridinium Chloride Mixture With 2,8-Diaminoacridine 3,6-Diamino-10-methylacridinium chloride 3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-diaminoacridine (proflav 3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-diaminoacridine (proflavine) 3,6-diamino-10-methylacridiniumchloridemixturewith3,6-acridinediamine ACRIFLAVINE Acriflavine Assiflavine Bialflavina Bovoflavin Buroflavin CI NO 46000 Diacrid EUFLAVINE Euflavine Flavacridinum hydrochloricum Flavine Gonacrine Isravin Mediflavin TRYPAFLAVINE TRYPAFLAVINE FS Trypaflavine Neutral Vetaflavin Xanthacridinum acridinium,3,6-diamino-10-methyl-,chloridemixedwith3,6-acridined
MDL NumberMFCD00064307
PubChem Substance ID443101
CAS Number8048-52-0
Reaxys-RN13329365
Merck Number123
Beilstein Registry Number22(5)11,323
Chemical Name Translation吖啶黄
Wiswesser Line NotationT C666 BKJ B1 EZ MZ &G &T C666 BNJ EZ MZ
LabNetwork Molecule IDLN00241972
InChIInChI=1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H
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分类

  • {SNA} A, Alphabetical, Fluorescent Stains, Nucleic Acid Stains, Stains & Dyes, A to Z, Stains and Dyes, 生化试剂, 细胞生物学, 荧光探针，标记，粒子和染色剂, 血液学和组织学
  • {SNA} Alphabetical, Biochemicals and Reagents,
  • {SNA} Alphabetical, Detection, Fluorescent Stains, Nucleic Acid Stains, Nucleic Acid Stains For Flow Cytometry, Nucleic Acid Stains For Microscopy, Protein Stains, Protein Stains For Flow Cytometry, Protein Stains for Microscopy, Wavelength Index, 发光化合物及其检测, 生化试剂, 荧光探针，标记，粒子和染色剂
  • Al
  • {SNA} Al
  • {SNA} A,

产品应用

  • Fluorescent label for high molecular weight RNA

相关文献及参考

  • [2]. Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Jun 2. pii: blood-2016-10-745588.
  • [3]. Yin T, et al. HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model. Oncol Res. 2014;22(3):139-45.
  • Merck 14 ,123
  • Merck: 14,123
  • Merck: 14,123 Beilstein:22(5)11,323
  • [1]. Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292.
  • [1]. Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292.
  • [2]. Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Jun 2. pii: blood-2016-10-

安全信息

RTECSAR9660000
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Hazard Codes
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S29 Do not empty into drains 不要排入下水道；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R50/53
UN Number UN 3077 9/PG 3
Packing GroupIII 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 160 mg/kg/60W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   SEMEAS Semana Medica.  (Sociedad Argentina de Gastroenterologica, Santa Fe
   1171, Buenos Aires, Argentina)  V.1-    1894-  Volume(issue)/page/year:
   159,778,1952

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 10 mg/L
REFERENCE :
   GENRA8 Genetical Research.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.1-    1960-  Volume(issue)/page/year: 7,207,1966

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 125,291,1984

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 5 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,11,1981

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   DMWOAX Deutsche Medizinische Wochenschrift.  (Stuttgart, Fed. Rep. Ger.)
   V.1-104, 1875-1979.  Volume(issue)/page/year: 92,2315,19

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Mammary gland
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   JOBIAO Journal of Biochemistry (Tokyo).  (Japanese Biochemical Soc., c/o
   Japan Academic Soc. Center, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.1- 
     1922-  Volume(issue)/page/year: 84,145,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25 umol/L
REFERENCE :
   JSPMAW Journal of Supramolecular Structure.  (Alan R. Liss, Inc., 41 E. 11th
   St., New York, NY 10003) V.1-    1972-  Volume(issue)/page/year: 1,449,1973

其他信息

  • 用途一:添加于李氏菌增菌肉汤基础中。
  • Sigma Aldrich:8048-52-0(sigmaaldrich)
  • MOL 文件:8048-52-0.mol
  • 吖啶黄价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0134 吖啶黄素(3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶的混合物) Acriflavine (mixture of 3,6-Diamino-10-methylacridinium Chloride and 3,6-Diaminoacridine) 25G 538元 2010/06/21 211400250 吖啶黄 Acriflavine neutral , 13.3-15.8% chlorine 25 GR 556元 2010/06/21 211401000 吖啶黄 Acriflavine neutral , 13.3-15.8% chlorine 100 GR 1562元
  • Acriflavine is a fluorescent label for high molecular weight RNA.
  • Acros Organics:吖啶黄 Acriflavine neutral, 13.3-15.8% chlorine(8048-52-0)
  • TCI Shanghai:吖啶黄素(3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶的混合物) Acriflavine (mixture of 3,6-Diamino-10-methylacridinium Chloride and 3,6-Diaminoacridine)(8048-52-0)
  • 图谱信息:吖啶黄(8048-52-0)红外图谱(IR1)

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Detection - Fluorescent Probes, Labels, Particles and Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Luminescent Compounds/Detection - Biochemicals and Reagents
  4. Wavelength Index - Luminescent Compounds/Detection
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Acridines
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Fluorescent Stains - Fluorescent Probes, Labels, Particles and Stains
  5. Nucleic Acid Stains - Fluorescent Stains
  6. Alphabetical - Nucleic Acid Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Fluorescent Stains
  5. Nucleic Acid Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Fluorescent Stains
  5. Nucleic Acid Stains
  6. Alphabetical
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Fluorescent Stains
  5. Nucleic Acid Stains
  6. Nucleic Acid Stains For Flow Cytometry
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Fluorescent Stains
  5. Protein Stains
  6. Protein Stains For Chromatography
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Fluorescent Stains
  5. Protein Stains
  6. Protein Stains For Immunoassays
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Stains
  6. Nucleic Acid Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Stains
  6. Nucleic Acid Stains
  7. Alphabetical
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Stains
  6. Nucleic Acid Stains
  7. Nucleic Acid Stains For Flow Cytometry
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Stains
  6. Protein Stains
  7. Protein Stains For Chromatography
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Stains
  6. Protein Stains
  7. Protein Stains For Immunoassays
  1. Medical Research Areas
  2. Metabolism
  3. HIF/HIF Prolyl-Hydroxylase  (缺氧诱导因子/缺氧诱导因子脯氨酸羟化酶)

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