(S)-2-Acetamido-N-((S)-1-Amino-4-Methyl-1-Oxopentan-2-yl)-4-Methyl-N-((S)-1-Oxohexan-2-yl)Pentanamide N-乙酰基-L-亮氨酰基-L-亮氨酰基-L-正亮氨酸醛

CAS 110044-82-1 MFCD00065505

化学结构图

110044-82-1
SMILES: CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C=O

化学属性

Mol. FormulaC20
Mol. Weight384

别名和识别编码

Chemical Name(S)-2-Acetamido-N-((S)-1-Amino-4-Methyl-1-Oxopentan-2-yl)-4-Methyl-N-((S)-1-Oxohexan-2-yl)Pentanamide
Synonym ALLN ALLN Ac-LLnL-CHO MG-101 N-Acetyl-Leu-Leu-Norleu-al N-Acetyl-L-leucyl-L-leucyl-L-norleucinal Ac-LLnL-CHO Calpain Inhibitor I MG-101 N-Acetyl-L-leucyl-L-leucyl-L-norleucinal N-Acetyl-Leu-Leu-Norleu-al
MDL NumberMFCD00065505
PubChem Substance ID24891066
Beilstein Registry Number7656053
CAS Number110044-82-1
Chemical Name TranslationN-乙酰基-L-亮氨酰基-L-亮氨酰基-L-正亮氨酸醛
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • {SNA} Aldehydes, Bioactive Small Molecules, Biochemicals and Reagents, Building Blocks, C-CH, C13-C60, Carbonyl Compounds, Cell Biology, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Type,
  • {SNA} Aldehydes, Building Blocks, C13-C60, Carbonyl Compounds, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Type, Organic Building Blocks, Substrate Analogs, 生化试剂, 酶、抑制剂和底物
  • {SNA} A to C, Aldehydes, Apoptosis Enzymes, Application Index, Bioactive

相关文献及参考

  • 1. Lu, Q., Mellgren, R.L., Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells. Arch. Biochem. Biophys. 334 , 175, (1996) 摘要
  • 2. Squier, M.K., Calpain activation in apoptosis. J. Cell Physiol. 159 , 229, (1994) 摘要
  • 3. Griscavage, J.M., Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κ B. Proc. Natl. Acad. Sci. U. S. A. 93 , 3308, (1996) 摘要
  • 4. Sherwood, S.W., In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetyl­leucylleucyl­norleucinal. Proc. Natl. Acad. Sci. U. S. A. 90 , 3353, (1993) 摘要
  • Hoffman, L., Rechsteiner M., Nucleotidase activities of the 26S proteasome and its regulatory complex. J. Biol. Chem. 271 , 32538, (1996) 摘要
  • Liu, D., et al., Activation of calpains mediates early lung neutrophili

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Aldehydes - Carbonyl Compounds
  6. C13-C60 - Aldehydes
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Substrate Analogs - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Calpain I - A to C
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Nitric Oxide and Cell Stress - Cell Signaling and Neuroscience
  5. Intracellular Protein Degradation - Nitric Oxide and Cell Stress
  6. Calpain and Proteasome Inhibitors - Intracellular Protein Degradation
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Nitric Oxide and Cell Stress
  5. Intracellular Protein Degradation
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Cathepsin/Granzyme Inhibitors & Substrates
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Enzyme Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Peptides for Cell Biology
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Apoptosis Enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Proteasome, Calpain and Lysosomal Proteases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Peptides
  4. Peptides for Cell Biology
  5. Cathepsin/Granzyme Inhibitors & Substrates
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Peptides
  4. Peptides for Cell Biology
  5. Enzyme Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Type
  6. Other
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Enzyme Inhibitors
  6. Calpain I
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Peptides for Cell Biology
  6. Cathepsin/Granzyme Inhibitors & Substrates
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Apoptosis Enzymes
  6. Calpain
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Apoptosis Enzymes
  6. Cathepsin G
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Proteasome, Calpain and Lysosomal Proteases
  6. Calpain
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Calmodulin-regulated enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Calpain
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Calpain I
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Catalase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Cathepsin G
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Peptides
  4. Peptides for Cell Biology
  5. Enzyme Inhibitors
  6. Calpain I
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Proteolytic Enzymes and Substrates
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Signal Transduction Research Tools
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Medical Research Areas
  2. Metabolism
  3. Proteasome  (蛋白酶体)

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