N,N’-Diisopropylcarbodiimide (DIC) N,N’-二异丙基碳二亚胺

CAS 693-13-0 MFCD00065689

化学结构图

693-13-0
SMILES: CC(C)N=C=NC(C)C

化学属性

Mol. FormulaC7H14N2
Mol. Weight126.20
Refractive index1.4300 to 1.4350
Boiling Point145-148°C at 760 mmHg
Density0.815
Flash Point31°C
TSCAYes
Stability对湿度敏感
Appearance 常温下为无色至微黄色透明液体,沸点145-148℃,不溶于水,溶于苯、乙醇、乙醚。
Melting Point210-212°C

别名和识别编码

Chemical NameN,N’-Diisopropylcarbodiimide (DIC)
Synonym N,N'-Diisopropylcarbodiimide(DIC) {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {} {} {} { {} {} {} {} {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {} {} {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {} {} {} {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {} {} {} {} {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Diisopropylcarbodiimide(DIC) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Diisopropylcarbo
CAS Number693-13-0
PubChem Substance ID12734
EC Number211-743-7
Beilstein Registry Number878281
MDL NumberMFCD00065689
Reaxys-RN878281
Alfabeta NameDIISOPROPYLCARBODIIMIDE NN-,'
Chemical Name TranslationN,N’-二异丙基碳二亚胺
LabNetwork Molecule IDLN00185440
InChIInChI=1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
Canonical SMILESCC(C)N=C=NC(C)C
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分类

  • {SNA} Carbodiimides, Chemical Biology, Chemical Synthesis, Coupling, DIG-DY, Peptide Chemistry, Peptide Coupling, Synthetic Reagents, 生物活性小分子, 细胞生物学
  • {SNA} Carbodiimides,
  • {SA} Bioactive Small Molecules, Carbodiimides, Cell Biology,

产品应用

  • A reagent for peptide synthesis.

相关文献及参考

  • Short: EINECS
  • Beilstein: 4,IV,531
  • Reagent for peptide coupling: J. Org. Chem., 44, 5000 (1979). Has the advantage over N,N'-Dicyclohexyl­carbodiimide, A10973 in solid phase peptide syntheses that the urea by-product is more soluble in organic solvents and hence more readily separated from the polymer support. For peptide reagents, see Appendix 6.
  • Short: IV/16

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H330 Fatal if inhaled 吸入致命
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes 6.1 T+ T+,T,F Xn
RTECSFF2175000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下,戴呼吸防护。
  • P302+P352
  • P303+P361+P353
  • P304+P340
  • P304+P340+P310
  • P304+P341
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P333+P313
  • P337+P313
  • P342+P311
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 2929
Risk Statements
  • R10 Flammable 易燃
  • R26 Very toxic by inhalation 吸入极毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R42/43
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S22 Do not breathe dust 不要吸入粉尘;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S38 In case of insufficient ventilation wear suitable respiratory equipment 通风不良时,佩带适当的呼吸器;
  • S4 Keep away from living quarters 远离生活区;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
Storage condition 2-8°C {LY} 2-8°C Moisture Sensitive Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Packing GroupI
Warnings IRRITANT
Hazard Class6.1/3

其他信息

  • Sigma Aldrich:693-13-0(sigmaaldrich)
  • Hazard Note:Flammable/Highly Toxic/
  • N,N′-Diisopropylcarbodiimide is an alternative to dicyclohexylcarbodiimide in peptide synthesis.
  • 图谱信息:N,N'-二异丙基碳二亚胺(693-13-0)核磁图( 1 HNMR) N,N'-二异丙基碳二亚胺(693-13-0)核磁图( 13 CNMR) N,N'-二异丙基碳二亚胺(693-13-0)红外图谱(IR1) N,N'-二异丙基碳二亚胺(693-13-0)质谱(MS) N,N'-二异丙基碳二亚胺(693-13-0)Raman光谱
  • MOL 文件:693-13-0.mol
  • 上游原料:二氯甲烷 --> 苯 --> 碳酸铅(II)(1:1) --> 分子筛,4A型,粉末< 50 微米 --> 二乙氧基二硫醚 --> 1,3-二异丙基-2-硫脲
  • 下游产品:4-(3-叔丁基-1,2,4-噁二唑-5-基)苯硼酸 --> 3-(2-氰基乙基甲酰氨)苯基硼酸 --> 4-(2-氰基乙基甲酰氨)苯基硼酸 --> 4-(3-叔丁基-1,2,4-恶二唑-5-基)苯甲醛 --> 3-叔丁基-5-(4-溴苄基)-1,2,4-恶二唑 --> 4-(哌啶-1-羰基)苯基硼酸
  • 存储注意事项:湿度敏感
  • 海关编码:29252000
  • TCI Shanghai:N,N'-二异丙基碳二亚胺 N,N'-Diisopropylcarbodiimide,>;97.0%(GC)(693-13-0)
  • Acros Organics:二异丙基碳化二亚胺/DIC N,N'-Diisopropylcarbodiimide,99%(693-13-0)
  • Alfa Aesar:N,N'-二异丙基碳二酰亚胺,99% N,N'-Diisopropylcarbodiimide, 99%(693-13-0)
  • 用途二:碳二亚胺类缩合剂,在多肽合成中,替代DCC的作用。所形成的脲副产物在有机溶剂中溶解性较好,较DCC形成的副产物更被容易除去。
  • F:10-21
  • MSDS 信息:N,N'-Diisopropylcarbodiimide(693-13-0).msds
  • 检测方法:GC,NMR
  • 对潮湿敏感,有臭味。对眼角膜有伤害,严重者可导致失明。水中分解。
  • 敏感性:Moisture Sensitive
  • N,N'-二异丙基碳二亚胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw020065 N,N’-二异丙基碳二酰亚胺 DIC (2-8℃) 100ml 500元 2011/04/16 D0254 N,N'-二异丙基碳二亚胺 N,N'-Diisopropylcarbodiimide 250G 3880元 2011/04/16 D0254 N,N'-二异丙基碳二亚胺 N,N'-Diisopropylcarbodiimide 25G 580元
  • 用途一:主要用作丁胺卡那霉素、谷胱甘肽等药物的脱水剂,也可用于酸酐、醛、酮、异氰酸酯的合成

系列性分类