• 原料直供
• 试剂商城
• 直接询价

分类

• B, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Chemopreventive Agents, Core Bioreagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glutathione biosynthesis and Glu-Cys Ligase, Research Essentials
• {SNA} Chemopreventive Agents, Core Bioreagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Glutathione biosynthesis and Glu-Cys Ligase, Research Essentials, 生化试剂, 癌症研究, 细胞生物学, 酶、抑制剂和底物
• {SNA} Core Bioreagents, D to K,

产品应用

• 抑制γ谷氨酰半胱氨酸合成酶（在谷胱甘肽合成中的一个关键酶）。

相关文献及参考

• ########
• 1. Broquist, H.P., Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: elucidation of glutathione and ascorbate in their role as antioxidants Nutr. Rev. 50 , 110-111, (1992)
• 2. Griffith, O.W., et al., Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis J. Biol. Chem. 257 , 13704-13712, (1982) 摘要
• Covey, T.M., et al., Alkylation Of The Tumor Suppressor PTEN Activates Akt And β-catenin Signaling: A Mechanism Linking Inflammation And Oxidative Stress With Cancer. PLoS ONE 5 , e13545, (2010) 摘要
• Chen, X., et al., Potential for selective modulation of glutathione in cancer chemotherapy. Chem. Biol. Interact. 111-112 , 263- 275, (1998)

安全信息

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   CBTOE2 Cell Biology and Toxicology.  (Princeton Scientific Pub., Inc., 301
   N. Harrison St., CN 5279, Princeton, NJ 08540)  V.1-    1984-
   Volume(issue)/page/year: 7,249,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3552 mg/kg
SEX/DURATION            : female 10-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 44,251,1991

其他信息

• 溶解于水。