Chlorhexidine dihydrochloride 氯己定二盐酸盐

CAS 3697-42-5 MFCD00068998

化学结构图

3697-42-5
SMILES: Cl.Cl.N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1

化学属性

Mol. FormulaC22H30Cl2N10
Mol. Weight578
Melting Point255-262°C
Solubility0.06 G/100 ML (20 ºC)
Density1.422

别名和识别编码

Chemical NameChlorhexidine dihydrochloride
CAS Number3697-42-5
Synonym ACTIDONE CHLOR (1S-(1ALPHA(S),3ALPH 放线酮 CHLORHEXIDINE DIHYDROCHLORIDE 1,6-BIS[N'-(P-CHLOROPHENYL)-N5-BIGUANIDO]HEXANE, 2HCL 1,6-DI(N-P-CHLOROPHENYL-DIGUANIDO)HEXANE DIHYDROCHLORIDE 3-[2-(3,5-DIMETHYL-2-OXOCYCLOHEXYL)-2-HYDROXYETHYL]GLUTARIMIDE ACTIDION AY-5312 Chlorhexidine dihydrochloride; Hexamethylenebis(5-(p-chlorophenyl)biguanide) dihydrochloride; Hibitane chlorhexidine dihydrochloride; 1,1'-Hexamethylenebis(5-(p-chlorophenyl))-biguanide dihydrochloride; AY 5312 BETA-[2-(3,5-DIMETHYL-2-OXOCYCLOHEXYL)-2-HYDROXYETHYL]GLUTARIMIDE 洗必泰盐酸盐 ACTIDIONE 1,1'-己基双[5-(对氯苯基)双胍]盐酸盐 N,N??-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide Dihydrochloride (N,N拻-BIS(4-CHLOROPHENYL-D8)-3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE DIHYDROCHLORIDE 3-[2-(3,5-二甲基-2-氧代环己基)-2-羧基乙基]戊二酰胺 ACTI-AID Arlacide H 1,6-BIS[N5-(P-CHLOROPHENYL)-N1-BIGUANIDO]HEXANE DIHYDROCHLORIDE 盐酸洗必泰 放线菌酮 4-[2-(3,5-DIMETHYL-2-OXO-CYCLOHEXYL)-2-HYDROXYETHYL]-2,6-PIPERIDINEDIONE ANTI-DIONE 双氯苯双胍己烷 二盐酸盐 Chlorhexidine dihydrochloride 1,1'-HEXAMETHYLENEBIS[5-(P-CHLOROPHENYL)BIGUA 氯己定二盐酸盐 1,6-BIS(P-CHLOROPHENYLDIGUANIDINO)HEXANE DIHYDROCHLORIDE 1,6-亚乙基二[N-甲基-N-(4-氯苯基)]哌 盐酸氯己定 氯己定 二盐酸盐 ay 5312 CHLORHEXIDINE 2HCL 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) dihydrochloride [1S-[1alpha(S*),3alpha,5beta]]-4-[2-(3,5- 1,6-双(N5-[对氯苯基]-N1-双胍)己烷；1,1′-己基双(5-[对氯苯基]双胍) 洗必泰 ACTI-AID(R) 1,6-双(N5-[对氯苯基]-N1-双胍)己烷；1,1′-己基双(5-[对氯苯基]双胍) 洗
MDL NumberMFCD00068998
PubChem Substance ID9571016
EC Number223-026-6
Reaxys-RN3850979
Merck Number2091
Beilstein Registry Number2384789
Chemical Name Translation氯己定二盐酸盐
LabNetwork Molecule IDLN00192965
InChIInChI=1S/C22H30Cl2N10.2ClH/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;;/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H
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分类

  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Standards, Analytical Standards, Chlorhexidine, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Metrological Institutes Standards,
  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Analytical Standards, Analytical/Chromatography, Chlorhexidine, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards
  • Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds, Organic Building Blocks
  • {SNA

产品应用

  • 本品为表面活性剂型杀菌剂，具有相当强的广谱抑菌、杀菌作用，对革兰阳性菌及革兰阴性菌均有效。外用消毒手、皮肤冲洗创口。

相关文献及参考

  • Foulkes, D.M., et al.: J. Periodontal Res., 8, 55 (1973),
  • Davies, G.E., et al.: Br. J. Pharmacol., 9, 192 (1954),
  • Merck: 14,2091

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P305+P351+P338+P337+P313
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi Xn,Xi
RTECSXA5285000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C 储存温度：2-8°C
UN Number UN 2811 6.1/PG 1 3077
Hazard Class9
Packing GroupIII 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 9,192,1954

其他信息

  • 用途:用作表面活性型杀菌剂，具有相当强的广谱抑菌、杀菌作用，对革兰氏阳性菌及革兰氏阴性菌均有效
  • MOL 文件:3697-42-5.mol
  • RTECS号:MA4375000
  • 图谱信息:盐酸氯己定(3697-42-5)红外图谱(IR2) 盐酸氯己定(3697-42-5)红外图谱(IR1) 盐酸氯己定(3697-42-5)质谱(MS)
  • 盐酸氯己定价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1254 盐酸氯己定 Chlorhexidine Dihydrochloride 25G 1240元
  • EPA化学物质信息:2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)- 3,12-diimino-, dihydrochloride(3697-42-5)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Guanidines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Guanidines - Nitrogen Compounds

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