Flupenthixol Dihydrochloride 盐酸氟哌噻吨

CAS 51529-01-2 MFCD00069278

化学结构图

51529-01-2
SMILES: Cl.Cl.OCCN1CCN(CC/C=C2/C3C=CC=CC=3SC3C=CC(=CC=3/2)C(F)(F)F)CC1

化学属性

Mol. FormulaC23H25F3N2OS · 2HCl
Mol. Weight507.44
Solubility可溶
Appearance solid

别名和识别编码

Chemical NameFlupenthixol Dihydrochloride
CAS Number51529-01-2
Synonym (4-[3-[2-TRIFLUOROMETHYL)-9H-THIOXANTHEN-9-YLIDENE]PROPYL]-1-PIPERAZINEETHANOL 2HCL (Z)-4-(3-[2-(TRIFLUOROMETHYL)-9H-THIOXANTHEN-9-YLIDENE]PROPYL)-1-PIPERAZINE-ETHANOL DIHYDROCHLORIDE (Z)-4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride (Z)-4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride Flupentixol dihydrochloride (Z)-4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]piperazine-1-ethanol dihydrochloride (Z)-4-[3-[2-(三氟甲基)-9H-硫杂蒽-9-亚基]丙基]-1-哌嗪基乙醇二盐酸盐 2-[4-[3-[(EZ)-2-(TRIFLUOROMETHYL)-9H-THIOXANTHEN-9-YLIDENE]PROPYL] PIPERAZIN-1-YL]ETHANOL DIHYDROCHLORIDE 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-1-piperazineethanold 4-(3-(2-trifluoromethylthioxanth-9-ylidene)propyl)-1-piperazineethanodih 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]- 4-[3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]piperazine-1-ethanol dihydrochloride CIS-(Z)-FLUPENTHIXOL DIHYDROCHLORIDE FLUPENTHIXOLDIHYDROCHLORIDE FLUPENTIXOL DIHYDROCHLORIDE FUPENTIXOL DIHYDROCHLORIDE Fluanxol dihydrochloride Flupentixol dihydrochloride cis-(Z)-Flupenthixol dihydrochloride flupentixolhydrochloride fx703 thioxanthene,9-(3-(4-(2-hydroxyethyl)piperazinyl)propylidene)-2-trifluoromethy 二盐酸氟哌噻吨 盐酸氟哌噻吨
MDL NumberMFCD00069278
PubChem Substance ID24278812
EC Number219-321-4
Chemical Name Translation盐酸氟哌噻吨
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分类

  • Pharmaceuticals
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Lundbeck, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Z, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators,

产品应用

  • Neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.

相关文献及参考

  • [2]. Philip Seeman, et al. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38.
  • Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973),
  • Peuch, et al.: Neuropharmacology, 20, 1279 (1981),
  • Post, M.L., et al.: Nature, 256, 342 (1975),
  • [1]. Jennifer M Wenzel, et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6.
  • [1]. Jennifer M Wenzel, et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6.
  • [2]. Philip Seeman, et al. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38.

安全信息

GHS Symbol
Precautionary statements
  • P301+P312+P330
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H302+H312+H332
WGK Germany3
Signal word Warning
RTECSTL9900000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
UN Number UN 2811 6.1/PG 3 2811

其他信息

  • MOL 文件:2413-38-9.mol
  • RTECS号:TL9900000
  • 非典型抗精神病药物:盐酸氟哌噻吨是非典型抗精神病药物氟哌噻吨的盐酸盐形式，为硫杂蒽类衍生物，具有强大的阻断多巴胺受体作用，除阻断D1、D2受体外，还能抑制 D2自身受体，使突触间 DA浓度增加。无镇静作用。抗精神病作用比泰尔登强 4～8倍。此外，尚有抗抑郁及抗焦虑作用。 临床上可用于急、慢性精神分裂症，其癸酸酯为长效剂。适用于淡漠退缩等精神分裂症的阴性症状，对焦虑及缺乏始动力者也有一定疗效。其癸酸酯长效制剂常用于慢性精神分裂症患者的维持治疗。 氟哌噻吨又称盐酸二氟噻吨、复康素、三氟噻吨、羟哌氟丙硫蒽，是一种硫杂蒽类非典型抗精神病药，常温下为白色或淡黄色粉末，味苦。溶于水、乙醇。其癸酸酯为黄色油状物，轻臭。此类药物的化学结构与吩噻嗪类抗精神病药基本相似，只是在吩噻嗪环上第10位氮原子被碳原子取代。药理作用与吩噻嗪类抗精神病药衍生物氟奋乃静相似，对淡漠、接触被动、意向减退、违拗等症状效果较好。另外本品具有较强的抗精神病作用，比氯普噻吨强4～8倍，同时还有抗焦虑、抑郁作用。作用机制是选择性地阻断中枢神经内的多巴胺受体，产生抗精神病作用。并可抑制脑内的神经元对去甲肾上腺素和5-羟色胺的再摄取，而产生抗抑郁作用。这类药物中主要有氯普噻吨(泰尔登)、替沃噻吨和氟哌噻吨。
  • color:white or off-white

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Dopaminergics - Neurotransmitters
  8. Antagonists - Dopaminergics
  1. Medical Research Areas
  2. GPCR & G Protein
  3. 5-HT Receptor  (5-羟色胺受体)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Dopamine Receptor  (多巴胺受体)

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