CAS 128-62-1 MFCD00069316-(S)-6,7-Dimethoxy-3-((R)-4-Methoxy-6-Methyl-5,6,7,8-Tetrahydro-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl)Isobenzofuran-1(3H)-One (S)-6,7-二甲氧基-3-((R)-4-甲氧基-6-甲基-5,6,7,8-四氢-[1,3]二氧杂环[4,5-g]异喹啉-5-基)异苯并呋喃-1(3H)-酮 TAO{mole}

(S)-6,7-Dimethoxy-3-((R)-4-Methoxy-6-Methyl-5,6,7,8-Tetrahydro-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl)Isobenzofuran-1(3H)-One (S)-6,7-二甲氧基-3-((R)-4-甲氧基-6-甲基-5,6,7,8-四氢-[1,3]二氧杂环[4,5-g]异喹啉-5-基)异苯并呋喃-1(3H)-酮

CAS 128-62-1 MFCD00069316

化学结构图

SMILES: COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C

化学属性

Mol. Formula	C₂₂H₂₃NO₇
Mol. Weight	413.43
Melting Point	174 - 176°C
Boiling Point

别名和识别编码

Chemical Name	(S)-6,7-Dimethoxy-3-((R)-4-Methoxy-6-Methyl-5,6,7,8-Tetrahydro-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl)Isobenzofuran-1(3H)-One
CAS Number	128-62-1
Synonym	(-)-?-Narcotine (-)-Narcotine (-)-α-Narcotine (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone (S,R)-Noscapine (S,R)-诺司卡品 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R,S)]- 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)- 1-α-Narcotine 6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isochinolin-5-yl)-1(3H)-isobenzofuranon, (S-(R,S))- ?-Narcotine Capval Coscopin Coscotabs Gnoscopin Hederix (free base) Key-Tusscapine L-alpha-Noscapine L-α-Noscapine Longactin Noscapi
MDL Number	MFCD00069316
PubChem Substance ID	275196
EC Number	204-899-2
Chemical Name Translation	(S)-6,7-二甲氧基-3-((R)-4-甲氧基-6-甲基-5,6,7,8-四氢-[1,3]二氧杂环[4,5-g]异喹啉-5-基)异苯并呋喃-1(3H)-酮
Wiswesser Line Notation	T C566 DO FO KN EH&&TJ HO1 K1 J- DT56 BVO DHJ HO1 IO1
InChI	InChI=1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1
LabNetwork Molecule ID	LN00244364

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产品应用

Antitussive.

安全信息

WGK Germany3

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSRD2625000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn

Risk Statements

R22 Harmful if swallowed 吞咽有害

Safety Statements

Precautionary statements

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 960 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 24,2331,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 853 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 24,2331,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1520 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 24,2331,1982

Storage condition -20