(-)-Sparteine (-)-鹰爪豆碱
CAS 90-39-1 MFCD00069653
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SA} Asymmetric Synthesis, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, Deprotonation
产品应用
- 用于手性二苯基甲烷的锂化/烷化中的非对称控制,以及在制备手性磷化氢配体中异构选择性地脱质子化。
- 和Cu(II)结合成有机催化剂,用于异构体选择性合成硝基醇醛。
相关文献及参考
- Chiral base used by Beak, Hoppe and others as chiral ligand in asymmetric lithiation reactions with alkyllithium reagents. High ee values are often obtained and the ligand can be easily recycled. For details of asymmetric lithiation of 1-Boc-pyrrolidine, see: J. Am. Chem. Soc., 116, 3231 (1994); Org. Synth. Coll., 9, 391 (1998); for comparison with other ligands, see: J. Org. Chem., 60, 8148 (1995). For reviews of asymmetric lithiation reactions of this type, see: Acc. Chem. Res., 29, 552 (1996), and of enantioselective synthesis with Li/sparteine carbanion pairs: Angew. Chem. Int. Ed., 36, 2283 (1997).
安全信息
GHS Symbol
- H332 Harmful if inhaled 吸入有害
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P332+P313
- P305+P351+P338+P337+P313
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P302+P350
- P337+P313
- R22 Harmful if swallowed 吞咽有害
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 960 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 210,27,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea REFERENCE : PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 50,420,1984
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1398,1935
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Amphibian - frog DOSE/DURATION : 1665 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1398,1935
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Ro