5,5-Diphenylhydantoin Sodium Salt 苯妥英钠
CAS 630-93-3 MFCD00069674
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
一流品牌服务
分类
- Anticonvulsants, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, DIG-DY, Enzymes, Inhibitors, and Substrates, Neurobiology, Neuroscience,
- {SNA} Anticonvu
- {SNA} Anticonvulsants, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling Enzymes, Cell Signaling and Neuroscience, DIG-DY, Enzymes, Inhibitors, and Substrates, Neurobiology, Neuroscience, Pharmacologicals, Substrates, Xenobiotics and Drug Metabolism, 细胞生物学
产品应用
- 苯妥英钠抑制神经元的快灭活型(T型)Ca2+通道,抑制Ca2+内流。较大浓度时,苯妥英钠能抑制K+外流,延长动作电位时程和不应期。
相关文献及参考
- Rush, A.M., and Elliott, J.R., Phenytoin and carbamazepine: differential inhibition of sodium currents in small cells from adult rat dorsal root ganglia. Neurosci. Lett. 226 , 95-98, (1997)
- Merck: 14,7322
- Merck 14 ,7322
安全信息
GHS Symbol



- H302 Harmful if swallowed 吞食有害
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P312+P330
- P308+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S22 Do not breathe dust 不要吸入粉尘;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- R22 Harmful if swallowed 吞咽有害
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R62 Possible risk of impaired fertility 有削弱生殖能力的危险
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 12571 ug/kg/25M-C TOXIC EFFECTS : Cardiac - pulse rate Cardiac - other changes Vascular - BP lowering not characterized in autonomic section REFERENCE : AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 6,255,1988
TYPE OF TEST : LDLo - Lowest publi
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 647 mg/kg/21W-I TOXIC EFFECTS : Skin and Appendages - dermatitis, allergic (after systemic exposure) REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 81,605,1948
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4056540
TYPE OF TEST : LDLo - L
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 153 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 14,253,1962
TYPE OF TEST : LDLo - Lowest published letha
TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 50 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Rodent - mouse Embryo DOSE/DURATION : 200 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 187,91,1987
TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Intravenous TEST SYSTEM : Rodent - mouse DOSE/DURATION : 500 ug/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 141,183,1984
TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 100 mg/L REFERENCE : VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1955- Volume(issue)/page/year: 99,257,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 1300 mg/kg SEX/DURATION : female 17-22 day(s) after conception lactating female 7 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 39,165,1987
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1200 mg/kg SEX/DURATION : female 7-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral REFERENCE : NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 17,627,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOS
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES O
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 189 mg/kg SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 64,271,1982
其他信息
- 无臭,味苦;微有吸湿性;在空气中渐渐吸收二氧化碳,分解成苯妥英;水溶液呈碱性反应,常因部分水解而发生浑浊;溶于水和乙醇,不溶于氯仿或乙醚。
- 苯妥英钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1331 5,5-二苯基乙内酰脲钠盐 5,5-Diphenylhydantoin Sodium Salt 500G 2450元 2014/06/02 D1331 5,5-二苯基乙内酰脲钠盐 5,5-Diphenylhydantoin Sodium Salt 25G 403元
- Sigma Aldrich:630-93-3(sigmaaldrich)
- 方法一:苯甲醛经缩合、氧化得到联苯甲酰,然后与尿素重排、环合得到苯妥英钠。将水、尿素及联苯甲酰依次加入反应锅,搅拌加热至98℃,加入30%氢氧化钠,回流1.5h。加水及适量少性炭脱色,冷至26-28℃,过滤,滤液用5%左右盐酸酸化至pH=5-6,温度45-55℃,过滤,用水洗涤,得苯妥英。将苯妥英投入碱液中加热溶解,用氢氧化钠溶液调节pH至11-11.5,加活万籁 炭于75-80℃脱色半小时。压滤,冷至37-38℃,加入晶种放置结晶。冷至25℃过滤,结晶用蒸馏水洗涤,甩干,粉碎,于80℃左右干燥,得苯妥英钠。
- 图谱信息:苯妥英钠(630-93-3)红外图谱(IR2) 苯妥英钠(630-93-3)红外图谱(IR1)
- 用途一:抗癫痫药及抗心律失常药。对癫痫大发作疗效好,对精神运动性发作和局限性发作次之,对小发作不但无效,甚至能诱发。
- MSDS 信息:5,5-Diphenylhydantoin sodium salt(630-93-3).msds
- 用途二:苯妥英钠抑制神经元的快灭活型(T型)Ca2+通道,抑制Ca2+内流。较大浓度时,苯妥英钠能抑制K+外流,延长动作电位时程和不应期。
- 上游原料:联苯甲酰
- MOL 文件:630-93-3.mol
- TCI Shanghai:苯妥英钠 5,5-Diphenylhydantoin Sodium Salt,>;98.0%(T)(630-93-3)