Diisopropanolnitrosamine N-亚硝基二异丙醇胺
CAS 53609-64-6 MFCD00070569
化学结构图
SMILES: CC(O)CN(CC(C)O)N=O
化学属性
| Mol. Formula | C6H14N2O3 |
|---|---|
| Mol. Weight | 162.22 |
别名和识别编码
| Chemical Name | Diisopropanolnitrosamine |
|---|---|
| CAS Number | 53609-64-6 |
| Synonym | N-Nitrosobis(2-hydroxypropyl)amine 1,1'-(Nitrosoimino)bis- 2,2'-Bishydroxypropylnitrosamine Di(2-hydroxypropyl)nitrosamine N-Bis(2-hydroxypropyl)nitrosamine BHP Diisopropanolnitrosamine DHPN 2-Propanol, 1,1'-(nitrosoimino)bis- N-Nitroso-N,N-di(2-hydroxypropyl)amine N,N-Di-(2-hydroxypropyl)nitrosamine 2-Propanol, 1,1'-nitrosoiminodi- DIPN 2,2'-Dihydroxy-di-n-propylnitrosoamine 2-Propanol, N-nitroso-1,1'-iminodi- |
| MDL Number | MFCD00070569 |
| Beilstein Registry Number | 2245909 |
| Chemical Name Translation | N-亚硝基二异丙醇胺 |
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分类
- Aliphatics
- Nitric Oxide Reagents
产品应用
- It shows carcinogenicity in the duct cells.
相关文献及参考
- Chang, P., et al.: Environ. Mol. Mutagen, 41, 43 (2003),
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6049 mg/kg/23W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - bronchiogenic carcinoma Liver - tumors REFERENCE : CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 9,257,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1400 mg/kg/2W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors REFERENCE : CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 63,1181,1979
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3560 mg/kg/20W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Gastrointestinal - tumors REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 58,361,1977
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1400 mg/kg/2W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors REFERENCE : CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher informa
TYPE OF TEST : TDLo - Lowest
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from large intestine REFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 63,181,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 9,257,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 4900 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Liver - hepatitis (hepatocellular necrosis), zonal Blood - hemorrhage REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 58,387,1977
TYPE OF TEST : Morphological transformation TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 5 mg/L REFERENCE : BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724) V.1- 19
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 6500 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 163,303,1986
{hazTYPE OF TEST : DNA damage TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 2 mmol/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 13,223,1992
TYPE OF TEST
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 250 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 111,135,1983
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 700 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,3463,1980
TYPE OF TEST : Host-mediated assay TEST SYSTEM : Rodent - hamster Bacteria - Salmonella typhimurium DOSE/DURATION : 400 mg/kg REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volu
