Cephalothin Sodium Salt 先锋霉素钠盐
CAS 58-71-9 MFCD00072025
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资金保障
专业采购外包团队在线服务
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分类
- {SNA} A - K, Antibacterial, Antibiotics A to Z, Antibiotics A-F, Chemical Structure Class, Interferes with Cell Wall Synthesis, Mechanism of Action, Penicillins and Cephalosporins (beta-Lactams), Spectrum of Activity, 抗生素, 生化试剂
- {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Biochemicals and Reagents, Chemical Structure Class,
- {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Chemical Structure Class, Interferes with Cell Wall Synthesis, Mechani
产品应用
- A first generation cephalosporin antibiotic with a wide range antibacterial activity. It is effective against gram-positive and gram-negative bacteria, and has been tested in respiratory disease and n
相关文献及参考
- Shibata, K., et al.: J. Antibiot., 50, 135 (1997); Farra, A., et al.: Int. J. Antimicrob. Agents., 31, 427 (2008); Pichardo, C., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 30, 289 (2011);
安全信息
GHS Symbol
- P342+P311
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- S22 Do not breathe dust 不要吸入粉尘;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S24 Avoid contact with skin 避免皮肤接触;
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S37 Wear suitable gloves 戴适当手套;
- R42/43
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - child DOSE/DURATION : 89 mg/kg/19D-I TOXIC EFFECTS : Blood - agranulocytosis REFERENCE : AACHAX Antimicr
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - man DOSE/DURATION : 955 mg/kg/22D-I TOXIC EFFECTS : Blood - agranulocytosis REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,272,1963
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5670 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 27,746,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on sei
其他信息
- 下游产品:头孢呋肟
- 储运特性:库房低温, 通风, 干燥
- 可燃性危险特性:可燃, 火场排出氮氧化物, 硫氧化物和氧化钠辛辣刺激烟雾
- 上游原料:醋酸钠 --> 乙酸丁酯 --> 7-氨基头孢烷酸 --> 噻吩乙酰氯
- MOL 文件:58-71-9.mol
- 毒性分级:低毒
- 急性毒性:口服- 大鼠 LD50: >;10000 毫克/ 公斤; 口服- 小鼠 LD: >; 10000 毫克/公斤
- MSDS 信息:58-71-9.msds
- 类别:有毒物品
- 方法一:以发酵生产的头孢菌素C为原料,经保护性水解得7-氨基头孢烷酸(7-ACA),与噻吩乙酰氯缩合,所得产物经乙酸丁酯提取,活性炭脱色,最后加入甲醇醋酸钠成盐,结晶而得头孢噻吩钠。
- Sigma Aldrich:58-71-9(sigmaaldrich)
- 灭火剂:水, 二氧化碳, 干粉, 砂土
- 用途二:广谱繁殖期杀菌型抗生素,对青霉素酶稳定,抗革兰阳性菌作用很强
- 用途三:该品为广谱繁殖期杀菌型抗生素。主要用于耐青霉素G的细菌引起的感染,如呼吸系统、胆道、泌尿道感染、金葡菌性脑膜炎、心内膜炎、败血症、扁桃体炎,骨髓炎和猩红热等。
- 用途一:广谱繁殖期杀菌型抗生素,对青霉素酶稳定,抗革兰氏阳性菌作用很强