Vitamin e succinate D-α-生育酚琥珀酸酯
CAS 4345-03-3 MFCD00072055
化学结构图
SMILES: Cc1c(C)c2c(c(C)c1OC(=O)CCC(=O)O)CC[C@@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O2
化学属性
| Mol. Formula | C33H54O5 |
|---|---|
| Mol. Weight | 530.78 |
| Melting Point | 73-77 |
| Density | 1.002 |
| Stability | 对热敏感 |
| Solubility | Soluble in DMSO, chloroform (50 mg/ml), and ethanol. Insoluble in water |
别名和识别编码
| Chemical Name | D-α-Tocopherol succinate, 96%, reference material |
|---|---|
| CAS Number | 4345-03-3 |
| Synonym | D-α-Tocopherol Succinate {LY} D-α-Tocopherol Succinate {} {LY} D-α-Tocopherol Succinate {} {} {LY} D-α-Tocopherol Succinate {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} Vitamin E succinate |
| MDL Number | MFCD00072055 |
| PubChem Substance ID | 20353 |
| Beilstein Registry Number | 4038233 |
| EC Number | 224-403-8 |
| Chemical Name Translation | D-α-生育酚琥珀酸酯 |
| Merck Number | 9495 |
| Reaxys-RN | 65995 |
| LabNetwork Molecule ID | LN00196324 |
| InChI | InChI=1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1 |
| Canonical SMILES | CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C(OC(CCC(O)=O)=O)=C1C)C |
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分类
- {SNA} Antioxidants and Cytoprotectants, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Lipids, Nitric Oxide and Cell Stress, Prenols, T, Vitamin E
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards A - B
- Analytical Standards, Analytical/Chromatography, Chromatography, Fat-Soluble Vitamins, Food & Beverage Standards, Market Segments, Neats and Solutions,
- {SNA} Antioxidants and Cytoprotectants,
- {SN
产品应用
- A potent antioxidant tocopherol
相关文献及参考
- Weber, T. et al.: Clin. Can Res., 8, 863 (2002);Staphelberg, M. et al.: Biochem. Biophys. Res. Comm., 318, 636 (2004); Ramathapuram, L.V. et al.: Cancer Immunol. Immununother., 55, 166 (2005);
- Merck 14 ,9495
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >7 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 25,273,1977
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
其他信息
- D-α-Tocopheryl Succinate is a potent antioxidant tocopherol. At high concentrations it has been shown to trigger caspase-mediated apoptosis of certain cells and, at low concentrations, inhibit proliferation. Mechanistic studies suggest that this compound down-regulates the fibroblast growth factor receptor-1 (FGFR1). Other experiments report that D-α-Tocopheryl Succinate also targets ASK 1, GADD 45β, and MEK-4, three key components of stress-activated mitogen-activated protein kinase pathway.
- F:8-10-23
- MOL 文件:4345-03-3.mol
- MSDS 信息:D-alpha-Tocopherol succinate(4345-03-3).msds
- Sigma Aldrich:4345-03-3(sigmaaldrich)
