CAS 366-70-1 MFCD00072082-Procarbazine Hydrochloride 盐酸甲基苄肼 TAO{mole}

Procarbazine Hydrochloride 盐酸甲基苄肼

CAS 366-70-1 MFCD00072082

化学结构图

SMILES: CNNCc1ccc(C(=O)NC(C)C)cc1.Cl

化学属性

Mol. Formula	C12H19N3O·HCl
Mol. Weight	257.76
Melting Point	223 ºC
Solubility	Soluble in water (52 mg/ml at 25 °C), DMSO (≥18 mg/ml), methanol, and ethanol (52 mg/ml at 25 °C).

别名和识别编码

Chemical Name	Procarbazine Hydrochloride
CAS Number	366-70-1
Synonym	1-(p-isopropylcarbamoylbenzyl)-2-methylhydrazinehydrochloride 1-methyl-2-(p-isopropylcarbamoylbenzyl)hydrazinehydrochloride 1-methyl-2-p-(isopropylcarbamyol)benzohydrazinehydrochloride 2-(p-(isopropylcarbamoyl)benzyl)-1-methylhydrazinehydrochloride Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-, Mutulane N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride N-Isopropyl-(2-methylhydrazino)-p-toluamide Hydrochloride N-异丙基-4-((2-甲基肼)甲基)苯甲酰胺盐酸盐 Natulan PROCARBAZINE HCL PROCARBAZINE HYDROCHLORIDE Procarbazine hydrochloride chlorhydratede1-methyl2p(isopropylcarbamoyl)benzyl-hydrazine ibenzmethyzinehydrochloride ibenzmethyzinhydrochloride ibz matulane n-(1-methylethyl)-4-((2-methylhydrazino)methyl)-benzamidmonohydrochlorid n-(1-methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidehydrochloride n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidhydrochloride n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidmonohydrochloride n-isopropyl-p-(2-methylhydrazinomethyl)benzamidehydrochloride natulanhydrochloride nci-c01810 nsc-77213 甲基苄肼盐酸盐盐酸甲基苄肼盐酸甲基苄肼; 甲基苄肼盐酸盐; N-异丙基-4-((2-甲基肼)甲基)苯甲酰胺盐酸盐酸丙卡巴肼
MDL Number	MFCD00072082
EC Number	206-678-6
Chemical Name Translation	盐酸甲基苄肼
Wiswesser Line Notation	1Y1&MVR D1MM1 &GH
PubChem Substance ID	9703
Reaxys-RN	4024454
Merck Number	7758
LabNetwork Molecule ID	LN00236010
InChI	InChI=1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H

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产品应用

An antineoplastic agent.

安全信息

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P201 Obtain special instructions before use. 使用前获取专门指示。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P405 Store locked up. 上锁保管。
P301+P312+P330
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P308+P313

Hazard statements

H350 May cause cancer 可能致癌
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H302 Harmful if swallowed 吞食有害

WGK Germany3

Signal word Danger

Hazard Codes T

Risk Statements

R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
R45 May cause cancer 可能致癌
R22 Harmful if swallowed 吞咽有害

Storage condition 储存温度 2-8C 储存温度-20°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1170 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Brain and Coverings - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-19,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - tumors
   Skin and Appendages - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   40,1027,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2340 mg/kg/42W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Brain and Coverings - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-19,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Endocrine - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (

RTECSXS4725000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 710 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 4,467,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSER

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,1467,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 785 mg/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - thrombocytopenia
   Immunological Including Allergic - decreased immune response
REFERENCE :
   EVSRBT Environmental Science Research.  (Plenum Pub. Corp., 233 Spring S

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1320 mg/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - thrombocytopenia
   Immunological Including Allergic - decreased immune response
REFERENCE :
   EVSRBT Environmental Science Research.  (Plenum Pub. Corp., 233 Spring St.,
   New York, NY 10013) V.1-    1972-  Volume(issue)/page/year: 24,977,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 116 umol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,1469,1981

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 130 mg/L
REFERENCE :
   EVSRBT Environmental Science Research.  (Plenum Pub. Corp., 233 Spring St.,
   New York, NY 10013) V.1-    1972-  Volume(issue)/page/year: 24,977,1981

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1550 umol/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,1469,1981

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 400 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V.,

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 10 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 80,265,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Neurospora crassa
DOSE/DURATION           : 1 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,193,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 360 mg/kg
SEX/DURATION            : female 8-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - body wall
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,381,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 200 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 120 mg/kg
SEX/DURATION            : female 1-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Vol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,365,1972

其他信息

MOL 文件:366-70-1.mol
上游原料:盐酸 --> 乙酸 --> N,N-二甲基甲酰胺 --> 氢化钠 --> 1,4-二氧六环 --> N-溴代丁二酰亚胺 --> 甲基肼 --> 氯甲酸苄酯 --> 对甲基苯甲酸甲酯
MSDS 信息:N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride(366-70-1).msds
Procarbazine hydrochloride
Procarbazine HCl是Procarbazine的盐酸盐形式，是一种多官能烷化剂化合物，是抗肿瘤剂。