CAS 77-67-8 MFCD00072123-3-Ethyl-3-Methylpyrrolidine-2,5-Dione 3-乙基-3-甲基吡咯烷-2,5-二酮 TAO{mole}

3-Ethyl-3-Methylpyrrolidine-2,5-Dione 3-乙基-3-甲基吡咯烷-2,5-二酮

CAS 77-67-8 MFCD00072123

化学结构图

SMILES: CCC1(C)CC(=O)NC1=O

化学属性

Mol. Formula	C7H11NO2
Mol. Weight	141
Boiling Point	150°C/12mmHg(lit.)
Melting Point	48.0 to 52.0 deg-C

别名和识别编码

Chemical Name	3-Ethyl-3-Methylpyrrolidine-2,5-Dione
CAS Number	77-67-8
Synonym	2-Ethyl-2-methylsuccinimide 3-Ethyl-3-methyl- 3-Ethyl-3-methyl-2,5-pyrrolidine-dione 3-Ethyl-3-methylpyrrolidine-2,5-dione 3-Methyl-3-ethylpyrrolidine-2,5-dione Aethosuximide Asamid Atysmal CI 366 Capitus Emeside Epileo Petit MAL Ethosuccimid Ethosuccimide Ethosuccinimide Ethosuxide Ethosuximide Ethylmethylsuccimide Ethymal Etomal Etosuximida Etosuximida Faes Faes, Etosuximida H 940 Mesentol PM 671 Pemal Pemalin Pentinimid Petinimid Petnidan Pyknolepsinum Ronton Simatin(E) Succimal Succimitin Suksilep {hazard_com
MDL Number	MFCD00072123
PubChem Substance ID	3291
EC Number	201-048-7
Reaxys-RN	117054
Beilstein Registry Number	21(5)9,595
Merck Number	3748
Chemical Name Translation	3-乙基-3-甲基吡咯烷-2,5-二酮
Wiswesser Line Notation	T5VMVTJ D2 D1
LabNetwork Molecule ID	LN01309260
InChI	InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

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产品应用

Anticonvulsant.

安全信息

WGK Germany3

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSWN2800000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Hazard Codes Xn

Risk Statements

R22 Harmful if swallowed 吞咽有害

Storage condition 0-10 0-10°C 储存温度2-8°C

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P312
P301+P312+P330
P330 Rinse mouth. 漱口
P501 Dispose of contents/container to..… 处理内容物/容器.....

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 780 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   NEPHBW Neuropharmacology.  (Pergamon Press Ltd., Headington Hill Hall,
   Oxford OX3 OBW, UK) V.9-    1970-  Volume(issue)/page/year: 24,427,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1810 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,117,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1325 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4188398

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1530 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   EPILAK Epilepsia (New York).  (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1-    1959-
   Volume(issue)/page/year: 4(4),66,1963

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 30 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 204,623,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 33300 ug/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
   In New Drugs, Proceedings of the Symposium on Toxicological Testing for
   Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
   Czechoslovakia, Univerzita Karlova, 1979  Volume(issue)/page/year: -,59,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 66600 ug/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
   In New Drugs, Proceedings of the Symposium on Toxicological Testing for
   Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
   Czechoslovakia, Univerzita Karlova, 1979  Volume(issue)/page/year: -,59,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 185 mg/kg
SEX/DURATION            : female 6-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   40YJAX "Evaluati