CAS 596-51-0 MFCD00072137-Glycopyrrolate bromide 甘罗溴铵 TAO{mole}

Glycopyrrolate bromide 甘罗溴铵

CAS 596-51-0 MFCD00072137

化学结构图

SMILES: C[N+]1(C)CCC(OC(=O)C(O)(c2ccccc2)C2CCCC2)C1.[Br-]

化学属性

Mol. Formula	C19 H28 N O3 . Br
Mol. Weight	398.33
Appearance	白色结晶性粉末，无臭，味苦。在水、甲醇或乙醇中易溶，在氯仿或乙醚中几乎不溶。熔点：191-195℃。
Stability	对湿度敏感、对热敏感
Melting Point	195

别名和识别编码

Chemical Name	Glycopyrrolate bromide
CAS Number	596-51-0
Synonym	(1,1-Dimethyl-2,3,4,5-tetrahydropyrrol-3-yl) 2-cyclopentyl-2-hydroxy-2-phenyl-acetate bromide; Glycopyrronium bromide (1,1-dimethyl 1,1-dimethyl-3-hydroxypyrrolidiniumbromidealpha-cyclopentylmandelate 1-methyl-3-pyrrolidylalpha-phenylcyclopentaneglycolatemethobromide 3-(alpha-cyclopentylmandeloyloxy)-1,1-dimethylpyrrolidinium bromide AHR 504 GLYCOPYRRONIUM Gastrodyn Glycopyrrolate Glycopyrrolate Bromide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number	209-887-0
MDL Number	MFCD00072137
Chemical Name Translation	甘罗溴铵
Reaxys-RN	3642926
Merck Number	4501
PubChem Substance ID	253660366
Wiswesser Line Notation	T5KTJ A1 A1 COVXQR&- AL5TJ &E
Beilstein Registry Number	3642926
InChIKey	VPNYRYCIDCJBOM-UHFFFAOYSA-M
LabNetwork Molecule ID	LN01292944
Canonical SMILES	[Br-].C[N+]1(C)CCC(C1)OC(=O)C(O)(C2CCCC2)c3ccccc3

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产品应用

A synthetic, quaternary ammonium anticholinergic. Antispasmodic; preanesthetic medicant.

安全信息

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P302+P352+P332+P313+P362+P364
P305+P351+P338+P337+P313
P301+P312+P330
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H302 Harmful if swallowed 吞食有害

WGK Germany3

Signal word

Safety Statements

Hazard Codes Xi

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

RTECSUY4337630

Storage condition -20°C -20℃ 0-10 0-10°C 2-8°C 储存温度:2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 709 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   19,93,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 833 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - hair
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 7,627,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 196 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   17,361,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JMPCAS Journal of Medicinal and Pharmaceutical Chemistry.  (Washington,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 mg/kg
SEX/DURATION            : lactating female 1 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - postpartum
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 15,721,1978

其他信息

MOL 文件:596-51-0.mol
用途一:抗胆碱药。
Glycopyrrolate(Glycopyrronium Br)是竞争性毒蕈碱拮抗剂，可解痉挛。
MSDS 信息:(1,1-Dimethyl-2,3,4,5-tetrahydropyrrol-3-yl) 2-cyclopentyl-2-hydroxy-2-phenyl-acetate bromide(596-51-0).msds