卡那霉素B 硫酸盐 卡那霉素B 硫酸盐

CAS 29701-07-3 MFCD00078511

化学结构图

29701-07-3
SMILES: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)[C@@H](O)[C@@H]1O.OS(O)(=O)=O

化学属性

Mol. FormulaC18H37N5O10?
Mol. Weight484

别名和识别编码

Chemical NameD-Streptamine,O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4))-2-deoxy-, sulfate (1:1)
CAS Number29701-07-3
Synonym Bekanamycin sulfate Kanamycin B, sulfate (1:1) (salt) Kanamycin B sulfate salt Kanendomycin sulfate O-3-Amino-3-deoxy-?-D-glucopyranosyl-(1?6)-O-[2,6-diamino-2,6-dideoxy-?-D-glucopyranosyl-(1?4)]-2-deoxy-D-streptamine Sulfate Kanamycin B Sulfate Bekanamycin Sulfate Kanamycin B sulfate Aminodeoxykanamycin sulfate Ka Aminodeoxykanamycin Sulfate
MDL NumberMFCD00078511
PubChem Substance ID24881934
Beilstein Registry Number5235274
Chemical Name Translation卡那霉素B 硫酸盐
Wiswesser Line NotationT6OTJ B1Q CQ DZ EZ FO- BL6TJ AZ CQ EZ DO- BT6OTJ CQDZ EQ F1Q &..H2.S-O4
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分类

  • Amines
  • Oligosaccharides
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} A - K, Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Interferes with Protein Synthesis, Mechanism of Action, Spectrum of Activity

产品应用

  • Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congene

相关文献及参考

  • Ito, et al.: J. Antibiot., 17, 189 (1964),
  • Toda, S., et al.: J. Antibiot., 30, 1002 (1977),
  • Claes, P.J., et al.: Anal. Profiles Drug. Subs., 6, 259 (1977),

安全信息

WGK Germany2
RTECSWK1976500
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,742,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethi

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,742,1982

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TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 141 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,742,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5950 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - other changes
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai

系列性分类


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