CAS 57432-61-8 MFCD00078588-Ergoline-8-carboxamide,9,10-didehydro-N-(1-(hydroxymethyl)propyl)-6-methyl-,(8-beta-(S))-, (Z)-2-butenedioate (1:1) (salt) TAO{mole}

Ergoline-8-carboxamide,9,10-didehydro-N-(1-(hydroxymethyl)propyl)-6-methyl-,(8-beta-(S))-, (Z)-2-butenedioate (1:1) (salt)

CAS 57432-61-8 MFCD00078588

化学结构图

SMILES: CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2CC3=CNC4C=CC=C(C2=C1)C=43.OC(=O)/C=C\C(O)=O

化学属性

Mol. Formula	C24H29N3O6
Mol. Weight	456

别名和识别编码

Chemical Name	Ergoline-8-carboxamide,9,10-didehydro-N-(1-(hydroxymethyl)propyl)-6-methyl-,(8-beta-(S))-, (Z)-2-butenedioate (1:1) (salt)
CAS Number	57432-61-8
Synonym	Metenarin Erezingen N-[?-(Hydroxymethyl)propyl]-D-lysergamide Maleate Ergonovine, methyl-, maleate (1:1) USAF uctl-8 Methylergonovine maleate salt Methylergometrine maleate Methylergonovine maleate Erezin (8?)-9,10-Didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-ergoline-8-carbox-amide Maleate Basofortina Methergin Methylergobasine maleate Methergine Maleic acid, methyl ergonovine
PubChem Substance ID	24278543
EC Number	260-734-4
MDL Number	MFCD00078588
Chemical Name Translation
Wiswesser Line Notation	T C6656 1A P GN LM CUTT&&J EVMY2&1Q G1 &OV1U1VO 2

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产品应用

A metabolite of Methysergide. Semisynthetic ergot alkaloid. Oxytocic.

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H331 Toxic if inhaled 吸入中毒
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSKE5500000

Precautionary statements

P301+P310
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。

Signal word Danger

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Hazard Codes T

Risk Statements

R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 85 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than letha

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,828,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 187 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,828,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,828,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 nmol/L
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   8,169,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE                    : 4 ug/kg
SEX/DURATION            : female 36 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   JRPMAP Journal of Reproductive Medicine.  (2 Jacklynn Ct., St. Louis, MO
   63132)  V.3-    1969-  Volume(issue)/page/year: 33,771,1988