Sodium 2-Propylpentanoate 丙戊酸钠
CAS 1069-66-5 MFCD00078604
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Abbott,
- {SNA} Abbott, Anticonvulsants, Antitumor Agents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules for Epigenetic Research, Enzyme Inhibitors, Histone Deacetylase Inhibitors, Neurobiology, Neuroscience, Pharmacologicals,
- {SNA} An
- {SNA} Abbott, Anticonvulsants, Antitumor Agents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research,
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards S - T, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
- {SNA} Abbott
产品应用
- Antiepileptic; increases levels of GABA in the brain.
相关文献及参考
- Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979),
- Nau, H., et al.: Pharmacol. Toxicol., 69, 310 (1991),
- Hauke, J., et al., Survival Motor Neuron Gene 2 Silencing By DNA Methylation Correlates With Spinal Muscular Atrophy Disease Severity And Can Be Bypassed By Histone Deacetylase Inhibition. Hum. Mol. Genet. 18 , 304-17, (2009) 摘要
- Baltus, G.A., et al., A Positive Regulatory Role For The MSin3A-HDAC Complex In Pluripotency Through Nanog And Sox2. J. Thorac. Cardiovasc. Surg. 284 , 6998-7006, (2009) 摘要
- Taubøll, E., et al., Effects Of Levetiracetam And Valproate On Reproductive Endocrine Function Studied In Human Ovarian Follicular Cells. Epilepsia 50 , 1868-74, (2009) 摘要
- Kyriss, M.N., et al., Novel Functional Residues In The Core Domain Of Histone H2B Regulate Yeast Gene Expression And Silencing And Affect The Response To DNA Damage. Mol. Cell. Biol. 30 , 3503-18, (2010) 摘要
- Grimes, C.A. and Jope, R.S., Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen-activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells. J. Neurochem. 73 , 1384-1392, (1999)
- Della Paschoa, O.E., et al., Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate. Br. J. Pharmacol. 125 , 1610-1616, (1998) 摘要
- Merck 14 ,9913
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
- R22 Harmful if swallowed 吞咽有害
- R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P312+P330
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - muscle weakness REFERENCE : PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issu
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 214 mg/kg/30D-I TOXIC EFFECTS : Skin and Appendages - dermatitis, allergic (after systemic exposure) REFERENCE : IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965- Volume(issue)/page/year: 30,283,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1468 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,41,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia REFERENCE : PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,58,1979
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 5 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 243,63,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 1620 mg/kg SEX/DURATION : female 1-39 week(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - hepatobiliary system REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,1518,1987
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 5200 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : ChaEB# Personal Communication from E.B. Chappel, Abbott Labs., N. Chicago, IL, Jan. 19, 1978 Volume(issue)/page/year: 19JAN1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DO
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE : 3 gm/kg SEX/DURATION : female 21-50 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 38,329,1988
其他信息
- MSDS 信息:2-Propylpentanoic acid sodium salt(1069-66-5).msds
- Sigma Aldrich:1069-66-5(sigmaaldrich)
- MOL 文件:1069-66-5.mol
- 外观:白色结晶或结晶性粉末
- 用途一:1069-66-5(丙戊酸钠)是一种不含氮的广谱抗癫痫药,用于治疗和预防各种类型癫痫,对失神性小发作、癫痫性行动失常等疗效更好。
- Acros Organics:丙戊酸钠 2-Propylpentanoic acid, sodium salt, 98%(1069-66-5)
- 丙戊酸钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 271830050 丙戊酸钠 2-Propylpentanoic acid, sodium salt 98% 5 GR 260元 2010/06/21 271830250 丙戊酸钠 2-Propylpentanoic acid, sodium salt 98% 25 GR 690元
- 质量标准:碱 度 PH 值应为7.5-9.0 干燥失重 ≤3.0% 重 金 属 不得过百万分之二十 甲醇残留量 ≤0.01% 甲苯残留量 ≤0.089% 含量测定 按干燥品计算,含C18H15NO3不得少于99.0%
- 上游原料:乙酰乙酸甲酯