3-((1-Benzyl-1H-Indazol-3-Yl)Oxy)-N,N-Dimethylpropan-1-Amine Hydrochloride 3-((1-苄基-1H-吲唑-3-基)氧基)-N,N-二甲基丙烷-1-胺盐酸盐
CAS 132-69-4 MFCD00078957
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专业采购外包团队在线服务
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分类
- Heterocycles
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, B, BA - BH, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, 分析/色谱
- Pharmaceuticals
- Amines
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, B, BA - BH, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds
- Intermediates & Fine Chemicals
- {SNA} Alphabetic, Analytical Standards, Analytical/Chromatography, B, BA - BH, Chromatography, Drugs & Metabolites,
产品应用
- A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.
相关文献及参考
- Passali, D., et al.: Clin. Ther., 23, 1508 (2001),
安全信息
GHS Symbol

- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P305+P351+P338
- P305+P351+P338+P337+P313
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P337+P313
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- R36 Irritating to eyes 刺激眼睛
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST : TDLo - Low
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,148,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 218 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness REFERENCE : TXAPA9 Toxicology and Applied Pharmacology
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 740 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 99,240,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 720 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 240 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : SKNEA7
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 900 mg/kg SEX/DURATION : female 10-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 600 mg/kg SEX/DURATION : female 8-13 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,271,1969
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 180 mg/kg SEX/DURATION : female 10-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,271,1969
TYPE OF TEST : TDL
TYPE OF TEST : TDLo - Lowest published toxic dose
其他信息
- 储运特性:通风低温干燥; 与库房食品原料分开存放
- 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物和氯化氢烟雾
- 毒性分级:高毒
- 苄达明 盐酸盐
- 方法一:以邻氨基苯甲酸为原料,经重氮化、还原、环合、烃化、缩合、成盐等化学反应生成苄达明。具体操作如下:(1)重氮化 边搅拌边将邻氨基苯甲酸加入一定量水中,加浓盐酸,使反应物溶解,再加盐酸使结晶析出。冷至3℃以下,缓缓滴加亚硝酸钠水溶液,温度不超过3℃,继续搅拌,得透明茶色重氮盐溶液。(2)还原 在10℃以下,将重氮盐溶液滴入二氧化硫饱和溶液中,静置后加浓盐酸,搅拌下有结晶析出,冷至5℃以下,放置、过滤、抽干得邻肼基苯甲酸盐酸盐。(3)环合 将还原物以及水、盐回流30分钟、浓缩、趁热用碳酸钠中和至pH为7,放置,过滤、水洗、干燥,得3-羟基吲哒唑。(4)烃化 将环合物及无水乙醇、氢氧化钠加热回流,冷后过滤,滤液冷冻过夜析出结晶,过滤、干燥,即得1-苄基-3-羟基吲哒唑。(5)缩合 将烃化物、二甲苯及切碎的金属钠加热回流,边搅拌边升温至金属钠融化,有白色气体产生。停止加热,反应物变稠至糊状,滴加二甲氨基氯丙烷与甲苯的混合液,滴完后继续回流反应。放冷、过滤、用二甲苯洗。将滤液与洗液合并,用稀盐酸萃取,加液碱,析出油层,以无水硫酸钠干燥。此即为苄达明游离碱,精制后按常法制成盐酸盐。
- Sigma Aldrich:132-69-4(sigmaaldrich)
- MOL 文件:132-69-4.mol
- 急性毒性:口服-大鼠 LD50: 740 毫克/公斤; 口服-小鼠 LD50: 440 毫克/公斤
- 上游原料:Α-球蛋白 --> 二氧化硫 --> 邻氨基苯甲酸 --> 稀盐酸 --> 2-肼基苯甲酸盐酸盐 --> 6,7,8-三氟-1,4-二氢-4-氧代-喹啉-3-羧酸乙酯 --> 茶色 --> 苄达明
- 用途一:本品为非特异性消炎药物,具有消炎,解热、镇痛作用。对因炎症引起的疼痛有效。抗炎作用与保泰松相似或稍强。本品尚有罂粟碱样解痉作用。常用于手术及外伤所致的各种炎症及关节炎、气管炎、咽炎等。可与抗菌素或磺胺类合用疗效更好。
- 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
- 类别:有毒物品