CAS 14984-68-0 MFCD00079012-Cloperastine Hydrochloride 咳平盐酸盐 TAO{mole}

Cloperastine Hydrochloride 咳平盐酸盐

CAS 14984-68-0 MFCD00079012

化学结构图

SMILES: Cl.ClC1C=CC(=CC=1)C(OCCN1CCCCC1)C1C=CC=CC=1

化学属性

Mol. Formula	C20H24ClNO·HCl
Mol. Weight	366.33
Melting Point	150.0 to 154.0 deg-C

别名和识别编码

Chemical Name	Cloperastine Hydrochloride
Synonym	Cloperastina cloridrato 1-(2-((p-Chloro-alpha-phenylbenzyl)oxy)ethyl)piperidine hydrochloride 4-Chlorobenzhydryl 2-(1-piperidyl)ethyl ether hydrochloride; 1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidinium chloride 咳平盐酸盐 Cloperastine hydrochloride 2-Piperidinoethyl p-chlorobenzhydryl ether hydrochloride 1-(2-(p-Cloro-alpha-fenilbenzilossi)etil)piperidina cloridrato
MDL Number	MFCD00079012
PubChem Substance ID	253660738
EC Number	239-067-8
CAS Number	14984-68-0
Reaxys-RN	3762484
Merck Number	2395
Chemical Name Translation	咳平盐酸盐

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安全信息

RTECSTM6491500

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

WGK Germany3

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 553 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   122,384,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1986 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   122,384,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 80,1759,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   122,384,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P312+P330
P501 Dispose of contents/container to..… 处理内容物/容器.....