CAS 73-05-2 MFCD00079268-Phentolamine Hydrochloride 盐酸苯酚胺 TAO{mole}

Phentolamine Hydrochloride 盐酸苯酚胺

CAS 73-05-2 MFCD00079268

化学结构图

SMILES: Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1.Cl

化学属性

Mol. Formula	C17H20ClN3O
Mol. Weight	318

别名和识别编码

Chemical Name	Phentolamine Hydrochloride
CAS Number	73-05-2
Synonym	Regitine Hydrochloride C-7337 3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino)phenol 2-[N-(3-Hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride 3-[[(4,5-Dihydro-1H-imidazol-2-yl)-methyl](4-methylphenyl)-amino]-phenol monohydrochloride 3-[4,5-Dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol hydrochloride 2-[N-(3-Hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride 酚妥拉明盐酸盐 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Hydrochloride 盐酸酚妥拉明 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-phenol Hydrochloride 3-[[(4,5-Dihydro-1H-imidazol-2-yl)-methyl](4-methylphenyl)-amino]-phenol monohydrochloride DNP
MDL Number	MFCD00079268
Beilstein Registry Number	3764617
EC Number	200-793-5
PubChem Substance ID	5702144
Chemical Name Translation	盐酸苯酚胺
LabNetwork Molecule ID	LN00676074
InChI	InChI=1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H

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分类

{SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
Heterocycles
{SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Fluorination Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Novartis, P-PH, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
Diagnostic

产品应用

An adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSSL0701000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 71,70,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 71,70,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 71,70,1949