Ketotifen Fumarate 富马酸酮替芬
CAS 34580-14-8 MFCD00079394
化学结构图
SMILES: CN1CCC(CC1)=C1C2C=CSC=2C(=O)CC2C=CC=CC1=2.OC(=O)/C=C/C(O)=O
化学属性
| Mol. Formula | C19H19NOS·C4H4O4 |
|---|---|
| Mol. Weight | 426 |
| TSCA | No |
| Melting Point | 192 |
别名和识别编码
| Chemical Name | Ketotifen Fumarate |
|---|---|
| CAS Number | 34580-14-8 |
| Synonym | 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one (2E)-2-Butenedioate HC 20-511 fumarate Ketotifen Hydrogen Fumarate Ketotifen fumarate Ketotifen fumarate salt Totifen Zaditen Zaditor Zasten |
| MDL Number | MFCD00079394 |
| PubChem Substance ID | 125307327 |
| EC Number | 252-100-0 |
| Merck Number | 5307 |
| Reaxys-RN | 4089486 |
| Chemical Name Translation | 富马酸酮替芬 |
| Beilstein Registry Number | 4089486 |
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信息真实价格透明
资金保障
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分类
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Histaminergics, Histaminergics - Antagonists, K, Membrane Protein Biology Tools,
产品应用
- Ketotifen is used as an antiasthmatic. Ketotifen is an antiallergic agent.
相关文献及参考
- [2]. Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35(1):1322-1330.
- Al O., et al.: J., Mol., Liq., 155, 103 (2010),
- Tsuji, F., et al.: Biol. Pharm. Bull., 33, 1050 (2010),
- Uccello-Barretta, G., et al.: Int. J. Pharm., 395, 122 (2010),
- [1]. Klooker TK, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010 Sep;59(9):1213-21.
- [1]. Klooker TK, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010 Sep;59(9):1213-21.
- [2]. Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35(1):1322-1330.
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R22 Harmful if swallowed 吞咽有害
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P312+P330
- P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 360 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,4069,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 370 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,4069,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : DRSAEA Drug Safety. (Adis International Ltd., Private Bag 65901, Mairangi Bay, Auckland 10, New Zealand) V.5- 1990- Volume(issue)/page/year: 7,387,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 286 ug/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Cardiac - pulse rate REFERENCE : DRSAEA Drug Safety. (Adis International Ltd., Private Bag 65901, Mairangi Bay, Auckland 10, New Zealand) V.5- 1990- Volume(issue
