(-)-Actinonin
CAS 13434-13-4 MFCD00080257
化学结构图
SMILES: CC(C)C(NC(=O)C(CC(=O)NO)CCCCC)C(=O)N1CCCC1CO
化学属性
| Mol. Formula | C19H35N3O5 |
|---|---|
| Mol. Weight | 385.50 |
别名和识别编码
| Chemical Name | Actinonin |
|---|---|
| CAS Number | 13434-13-4 |
| Synonym | ######## 3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid Actinonin Actinonine |
| MDL Number | MFCD00080257 |
| PubChem Substance ID | 24278232 |
| Beilstein Registry Number | 1555250 |
| Wiswesser Line Notation | T5NTJ AVYY1&1&MVY5&1VMQ B1Q |
| Chemical Name Translation |
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资金保障
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现货库存
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分类
- {SNA} A - K,
- {SA} A - K, A-AM, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Chemical Structure Class, Cytoskeleton and Extracellular Matrix, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Extracellular Matrix, Inhibits an Enzyme, L to O, Leucine Aminopeptidase,
- Inhibitors
- Chiral Reagents
- Heterocycles
- {SNA} A - K,
产品应用
- ########
相关文献及参考
- [2]. Chen DZ, et al. Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry. 2000 Feb 15;39(6):1256-62.
- [3]. Wahl, R.C., et al. Hydroxamate inhibitors of human gelatinase B (92 kDa). Bioorganic & Medicinal Chemistry Letters 5(4), 349-352 (1995).
- [4]. Duke SO, et al. Modes of action of microbially-produced phytotoxins. Toxins (Basel). 2011 Aug;3(8):1038-64.
- [5]. Kruse MN, et al. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochem J. 2004 Mar 1;378(Pt 2):383-9.
- Berg, A., et al.: Biochem., 48, 1584 (2009),
- Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (2009),
- Umezawa, H., et al.: J. Antibiot., 38, 1629 (1985),
- [1]. Lee MD,
- [1]. Lee MD, et al. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J Clin Invest. 2004 Oct;114(8):1107-16.
安全信息
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #167936
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,102,1967
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1629,1985
