Leupeptin Hemisulfate (S)-2-乙酰氨基-N-((S)-1-((S)-5-胍基-1-氧代戊烷-2-基)氨基)-4-甲基-1-氧代戊烷-2-基)-4-甲基戊酰胺半硫酸盐

CAS 103476-89-7 MFCD00037012

化学结构图

103476-89-7
SMILES:

化学属性

Mol. FormulaC40H76N12O8·H2SO4
Mol. Weight476

别名和识别编码

Chemical NameLeupeptin Hemisulfate
Synonym Acetyl-Leu-Leu-Arg-al N-乙酰基-L-亮氨酰-L-亮氨酰-L-精氨醛 半硫酸盐 Acetyl-Leu-Leu-Arg-al N-乙酰基-L-亮氨酰-L-亮氨酰-L-精氨醛 半硫酸盐 亮抑酶肽 半硫酸盐 N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt N-乙酰基-L-亮氨酰-L-亮氨酰-L-精氨醛 半硫酸盐 亮抑酶肽 亮抑酶肽 半硫酸盐
MDL NumberMFCD00037012
PubChem Substance ID57651875
CAS Number103476-89-7
Chemical Name Translation(S)-2-乙酰氨基-N-((S)-1-((S)-5-胍基-1-氧代戊烷-2-基)氨基)-4-甲基-1-氧代戊烷-2-基)-4-甲基戊酰胺半硫酸盐
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分类

  • {SNA} Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Core Bioreagents, Cysteine Protease Inhibitors, Enzyme Inhibitors, General Protease Inhibitors, Miscellaneous Peptides, Peptides and Proteins, Peptides for Cell Biology, Protease Inhibitors, Research Essentials,
  • {SNA} Enzyme Inhibitors, Enzyme Inhibitors by Type,

相关文献及参考

  • [2]. Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.
  • , Beynon, R.J. and Bond, ed. Proteolytic Enzymes: A Practical Approach , (1989), 244-245
  • 2. T. Aoyagi et al. J. Antibiot. 22 , 283, (1969) 摘要
  • 3. J. Antibiot. 22 , 558, (1969) 摘要
  • 4. H. Umezawa Meth. Enzymol. 45 , 678, (1976) 摘要
  • Aoyagi, T., Inhibitor of trypsin, plasmin, papain and cathepsin B. J. Antibiot. 22 , 283, (1969)
  • Deutscher, M.P., Maintaining protein stability. Meth. Enzymol. 182 , 83-89, (1990)
  • Jazwinski, S.M., Preparation of extracts from yeast. Meth. Enzymol. 182 , 154-174, (1990) 摘要
  • Logue, S.E., et al., Expression, purification and use of recombinant annexin V for the detection of apoptotic cells. Nat. Protoc. 4 , 1383-95, (2009) 摘要
  • Saino, T., et al. Chem. Pharm. Bull. 30 , 2319, (1982)
  • [1]. Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol
UN Number 3077
Hazard Codes 9
Signal word Warning
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S7/8 Keep container tightly closed and dry 保存在严格密闭容器中，保持干燥；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P304+P340
Packing GroupIII

系列性分类

  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Enzyme Inhibitors - Core Bioreagents
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Autophagy - Cell Signaling and Neuroscience
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Organic Covalent Modifiers - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. P to Q - Enzyme Inhibitors by Enzyme
  7. Proteases, serine and cysteine
  1. Functional Group 官能团索引
  2. sulfuric acid
  1. Medical Research Areas
  2. Metabolism
  3. Cathepsin  (组织蛋白酶)

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