CAS 134-63-4 MFCD00082455-Lobeline hydrochloride 盐酸洛贝林 TAO{mole}

Lobeline hydrochloride 盐酸洛贝林

CAS 134-63-4 MFCD00082455

化学结构图

SMILES: CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1.Cl

化学属性

Mol. Formula	C₂₂H₂₈ClNO₂
Mol. Weight	373.92
Melting Point	183-185 °C (dec.)(lit.)
Solubility	H2O: 25 mg/mL
Appearance	powder
Refractive index	-57.5 ° (C=1, H2O)

别名和识别编码

Chemical Name	Lobeline hydrochloride
MDL Number	MFCD00082455
CAS Number	134-63-4
Synonym	(-)-LOBELINE HCL (-)-LOBELINE HYDROCHLORIDE (-)-id (-)-洛贝林盐酸盐 2-(6-(2-hydroxy-2-phenethyl)-1-methyl-2-piperidyl)acetophenone hydrochloride 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-acetophenonhydrochlor 2-(6-[2-HYDROXY-2-PHENYLETHYL]-1-METHYL-2-PIPERIDINYL)-1-PHENYLETHANONE HYDROCHLORIDE 2-(6-[2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl)-1-phenylethanone, L-Lobeline, Hydrochloride 2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenyl-ethyl]-1-methyl-2-piperidyl]-1-phenyl-ethanone hydrochloride 2-[1-甲基-6-(beta-羟基苯乙基)-2-哌啶基]苯乙酮盐酸盐 2-[6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl]-,hydrochloride,(-)-Acetophenone 2-[6-(2-HYDROXY-2-PHENETHYL)-1-METHYL-2-PIPERIDYL]ACETOPHENONE HCL 2-[6-(2-羟基-2-苯乙基)-1-甲基-2-呱啶基]-1-苯乙酮盐酸盐 (-)-洛贝林盐酸盐 A-LOBELINE HCL A-LOBELINE, HYDROCHLORID
PubChem Substance ID	46202
EC Number	205-150-2
Beilstein Registry Number	3920196
Chemical Name Translation	盐酸洛贝林
Merck Number	5551
Wiswesser Line Notation	T6NTJ A1 B1YQR& F1VR &GH
LabNetwork Molecule ID	LN01871764
InChI	InChI=1S/C22H27NO2.ClH/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18;/h2-7,9-12,19-21,24H,8,13-16H2,1H3;1H

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安全信息

GHS Symbol

WGK Germany3

Hazard Codes T

Hazard statements

H331 Toxic if inhaled 吸入中毒
H301 Toxic if swallowed 吞食有毒
H301+H331

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

RTECSOJ8490100

Precautionary statements

P301+P310
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。

Signal word Danger

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒

Packing GroupIII

Hazard Class6.1(b)

UN Number UN 1544 6.1/PG 3

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,913,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 87500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,913,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 39900 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,913,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 163,279,1931

Storage condition -20

其他信息

TCI Shanghai:盐酸洛贝林 Lobeline Hydrochloride,>;98.0%(LC)(T)(134-63-4)
Sigma Aldrich:134-63-4(sigmaaldrich)
F:8
盐酸洛贝林价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 61003180 盐酸-L-山梗碱 g 165元
color:white to off-white
MOL 文件:134-63-4.mol