CAS 2152-34-3 MFCD00083197-Pemoline 匹莫林 TAO{mole}

Pemoline 匹莫林

CAS 2152-34-3 MFCD00083197

化学结构图

SMILES: NC1=NC(=O)C(c2ccccc2)O1

化学属性

Mol. Formula	C9H8N2O2
Mol. Weight	176.19
Appearance	solid 白色结晶性粉末。熔点256-257℃（分解）。难溶于水、醚、丙酮和稀盐酸。无臭无味。
Melting Point	255-256°C

别名和识别编码

Chemical Name	4-Oxazolidinone, 2-imino-5-phenyl-
Synonym	2-IMINO-5-PHENYL-4-OXAZOLIDINONE 2-亚氨基-5-苯基-4-噁唑烷酮 Hyton 2-Amino-5-phenyl-1,3-oxazol-4(5H)-one Sigmadyn Pemoline TRADON Pemolina FWH-352 5-Phenyl-2-imino-4-oxazolidinone Yh 1 Okodon Ronyl 培脑灵苯异妥英 2-amino-5-phenyl-2-oxazolin-4-one PT 360 2-亚氨基-5-苯基-4-恶唑烷酮 Pioxol PHENYLPSEUDOHYDANTOIN A 13397 Pondex Azoxodone 2-amino-5-phenyl-4(5h)-oxazolon Fenoxazol Deltamine Azoksodon 4-OXO-2-IMINO-5-PHENYLOXAZOLIDINE Notair Stimul 2-Imino-5-phenyl-4-oxazolidinone 2-AMINO-5-PHENYL-4-OXAZOLIDINONE 匹莫林 Tradon 4(5H)-Oxazolone, 2-amino-5-phenyl- Nitan 2-inino-5-phenyloxazolidin-4-one Dantromin 2-AMINO-5-PHENYL-4(5H)-OXAZOLONE Kethamed 2-AMIN-5-PHENYL-4(5H)-OXAZOLONE PEMOLINE PN/135 PHENOXAZOLE 2-amino-5-phenyl-2-oxazolin-4-on 2-imino-4-keto-5-phenyltetrahydrooxazole Phenylisohydantoin 2-亚氨基-5-苯基-4-唑烷酮 2-Amino-5-phenyl-4(5H)-oxazolone H 3104 LA 956 Sistra Phenoxazole PHENYLISOHYDANTOIN Endolin 翠雀它明 VOLITAL Centramin CS 293 2-imino-5-phenyl-4-oxazolidinon 4-Oxazolidinone, 2-imino-5-phenyl- 匹吗啉 Juston-wirkstoff Tradone Phenylpseudohydantoin
MDL Number	MFCD00083197
EC Number	218-438-8
Chemical Name Translation	匹莫林
CAS Number	2152-34-3
Wiswesser Line Notation	T5OYMV EHJ BUM ER
PubChem Substance ID	4723
InChI	InChI=1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)

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安全信息

GHS Symbol

WGK Germany3

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H332 Harmful if inhaled 吸入有害
H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害

RTECSRQ2975000

Signal word Warning

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Hazard Codes Xn

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R22 Harmful if swallowed 吞咽有害

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 373 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
   (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
   20037)  V.1-    1977-  Volume(issue)/page/year: 1,33,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 536 ug/kg
TOXIC EFFECTS :
   Behavioral - wakefulness
   Gastrointestinal - decreased motility or constipation
   Skin and Appendages - sweating
REFERENCE :
   JCPYDR Journal of Clinical Pyschopharmacology.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.1-    1981- Volume(issue)/page/year:
   3,331,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 365 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23,    1978-88. For
   publisher information, see ZYZAEU.  Volume(issue)/page/year: 18,343,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 365 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
   (American Pha

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   CAJPBD Proceedings of the Congenital Anomalies Research Association of
   Japan.  (Kyoto, Japan) No.1-    1961-  Volume(issue)/page/year: 3,2,1963

其他信息

MSDS 信息:Pemoline(2152-34-3).msds
MOL 文件:2152-34-3.mol
Sigma Aldrich:2152-34-3(sigmaaldrich)
用途一:该品为中枢神经兴奋药，兴奋作用中咖啡因的20倍，用于治疗脑功能失调症，轻型优郁症及发作性睡病等。但不良反应较多，逐渐被三环及四环类抗忧郁药所替代。大鼠口服LD50为500mg/kg。
color:white
上游原料:DL-扁桃酸
方法一:由苯甲醛经与氯仿缩合、水解得到α-羟基苯乙酸，再经酯化、环合而得匹莫林。