15-O-Acetyl-4-deoxynivalenol from Fusarium graminearum 15-O-乙酰脱氧瓜萎镰菌醇 来源于禾谷镰刀菌

CAS 88337-96-6 MFCD00083218

化学结构图

88337-96-6
SMILES: C[C@@]12C[C@@H](O)[C@@H](O[C@@H]3C=C(C)C(=O)[C@@H](O)[C@]13COC(C)=O)[C@]12CO1

化学属性

Mol. FormulaC17
Mol. Weight338

别名和识别编码

Chemical Name15-O-Acetyl-4-deoxynivalenol from Fusarium graminearum
CAS Number88337-96-6
Synonym 15-乙酰氧基-3alpha,7alpha-二羟基-12,13-环氧单端孢霉-9-烯-8-酮 15-ADON 15-AcDON 15-Acetylvomitoxin 15-Acetylvomitoxin 15-O-乙酰脱氧瓜萎镰菌醇 来源于禾谷镰刀菌 (3?,7?)-15-(Acetyloxy)-12,13-epoxy-3,7-dihydroxy-trichothec-9-en-8-one 15-O-Acetyl-4-deoxynivalenol Deoxynivalenol 15-Acetate 15-O-乙酰脱氧瓜萎镰菌醇 来源于禾谷镰刀菌 15-乙酰氧基-3α,7α-二羟基-12,13-环氧单端孢霉-9-烯-8-酮 15-乙酰脱氧瓜萎镰菌醇 溶液 15-乙酰脱氧瓜萎镰菌醇 15-Acetyldeoxynivalenol 15-乙酰氧基-3α,7α-二羟基-12,13-环氧单端孢霉-9-烯-8-酮
MDL NumberMFCD00083218
PubChem Substance ID24890561
EC Number200-835-2
Chemical Name Translation15-O-乙酰脱氧瓜萎镰菌醇 来源于禾谷镰刀菌
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分类

  • {SA} A, AA to AL, Alphabetic, Analytical Standards, Analytical/Chromatography, Biotoxins, Chromatography,
  • Analytical Standards, Analytical/Chromatography, Application CRMs, Biotoxins, CRM & Matrix RM, Certified Reference Materials (CRMs), Chromatography, Food and Agriculture CRM, Life Sciences Standards, Mycotoxins, Neat, Other
  • {S
  • {SNA} All alphabetically sorted, Analytical Standards, Biotoxin and Mycotoxin Standards, Food and Cosmetic Component Standards, Mycotoxins, Single component solutions, 分

产品应用

  • A mycotoxin produced by the fungi Fusarium culmorum and Fusarium graminearum, inhibits protein synthesis.

相关文献及参考

  • Ashraf, A.; et al.: Int. J. Biol. Biotechnol., 4, 391 (2007),
  • Burlakoti, R., et al.: App. Environ. Microbiol., 74, 6513 (2008),
  • Steinmetz, W., et al.: Eur. J. Med. Chem., 44, 4485 (2009),
  • [1]. Juan-García A, et al. Binary and tertiary combination of alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol on HepG2 cells: Toxic effects and evaluation of degradation products. Toxicol In Vitro. 2016 Aug;34:264-273.

安全信息

RTECSYD0155000
GHS Symbol
WGK Germany3
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Signal word Danger
Hazard statements
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H300 Fatal if swallowed 吞食致命
Hazard Codes T F,Xn
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36 Irritating to eyes 刺激眼睛
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 113 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEMIDF Applied and Environmental Microbiology.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.31-    1976-
   Volume(issue)/page/year: 50,1304,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 34 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from small intestine
   Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
   Blood - changes in spleen
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   25,155,1987

系列性分类


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