3-(2-(4-(4-Fluorobenzoyl)Piperidin-1-Yl)Ethyl)Quinazoline-2,4(1H,3H)-Dione 3-(2-(4-(4-氟苯甲酰)哌啶-1-基)乙基)喹唑啉-2,4(1H,3H)-二酮
CAS 74050-98-9 MFCD00083392
化学结构图
SMILES: O=C1C2C=CC=CC=2NC(=O)N1CCN1CCC(CC1)C(=O)C1C=CC(F)=CC=1
化学属性
| Mol. Formula | C22H22FN3O3 |
|---|---|
| Mol. Weight | 395 |
| Melting Point | 231.0 to 235.0 deg-C |
别名和识别编码
| Chemical Name | 3-(2-(4-(4-Fluorobenzoyl)Piperidin-1-Yl)Ethyl)Quinazoline-2,4(1H,3H)-Dione |
|---|---|
| CAS Number | 74050-98-9 |
| Synonym | 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione Ketensin R 41468 |
| MDL Number | MFCD00083392 |
| Beilstein Registry Number | 4913068 |
| EC Number | 277-680-2 |
| Chemical Name Translation | 3-(2-(4-(4-氟苯甲酰)哌啶-1-基)乙基)喹唑啉-2,4(1H,3H)-二酮 |
| Reaxys-RN | 4913068 |
| Merck Number | 5296 |
| PubChem Substance ID | 253661148 |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- An antihypertensive, with affinity for multiple GPCR receptors.
相关文献及参考
- [2]. Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506.
- [3]. Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340(2):369-76.
- [4]. Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11(9):1471-1479.
- Brea, J., et al.: Mol. Pharmacol., 75, 1380 (2009),
- Shen, K., et al.: J. Pharm. Pharmacol., 61, 517 (2009),
- Zhu, Y., et al.: Biol. Pharm. Bull., 32, 1173 (2009),
- [1].
- [1]. Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155(3):365-73.
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P312+P330
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302 Harmful if swallowed 吞食有害
