Methazolamide 醋甲唑胺
CAS 554-57-4 MFCD00083416
化学结构图
SMILES: CC(=O)N=c1sc(S(N)(=O)=O)nn1C
化学属性
| Mol. Formula | C5H8N4O3S2 |
|---|---|
| Mol. Weight | 236.27 |
| Melting Point | 208 °C (dec.)(lit.) |
别名和识别编码
| Chemical Name | Methazolamide |
|---|---|
| CAS Number | 554-57-4 |
| Synonym | Acetamide, N-(5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene)- { n-(4-methyl-2-sulfamoyl-delta(2)-1,3,4-thiadiazolin-5-ylidene)-acetamid 2-Acetylimino-3-methyl-delta 2-Acetylimino-3-methyl-delta(sup 4)-1,3,4-thiadiazoline-5-sulfonamide 5-Acetylimino-4-methyl-delta -1,3,4-thiadiazoline-2-sulfonam Acetamide, N-(4-methyl-2-sulfamoyl-delta N-[(2E)-5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide Naptazane METHAZOLAM -1,3,4-thiadiazoline-5-sulfonamide 2-acetylimino-3-methyl-delta(sup4)-1,3,4-thiadiazoline-5-sulfonamide Neptazane 4 Acetamide, N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]- 5-Acetylimino-4-methyl-delta(sup 2)-1,3,4-thiadiazoline-2-sulfonamide 醋甲唑胺 n-(5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3h)-ylidene)-acetamid -1,3,4-thiadiazolin-5-ylidene)acetamide n-(4-methyl-2-sulfamoyl-delta(sup2)-1,3,4-thiadiazolin-5-ylidene)-acetamid 5-Acetylimino-4-methyl-·2-1,3,4-thiadiazoline-2-sulfonamide L 584601 N-(4-甲基-2-氨基磺酰基-Δ2-1,3,4-噻二唑-5-亚基)乙酰胺 N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide Neptazaneat 5-acetylimino-4-methyl-delta(sup2)-1,3,4-thiadiazoline-2-sulfonamide N-(4-Methyl-2-sulfamoyl-delta 5-Acetylimino-4-methyl-·2-1,3,4-thiadiazoline-2-sulfonamide N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide N-(4-甲基-2-氨基磺酰基-Δ2-1,3,4-噻二唑-5-亚基)乙酰胺 N-(3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidene)-acetamide n-(4-methyl-2-sulfamoyl-△2-1,3,4-thiadiazolin-5-ylidene) acetamide |
| MDL Number | MFCD00083416 |
| PubChem Substance ID | 4100 |
| EC Number | 209-066-7 |
| Chemical Name Translation | 醋甲唑胺 |
| Wiswesser Line Notation | T5NNYSJ B CUNV1 ESZW |
| Beilstein Registry Number | 0232387 |
| LabNetwork Molecule ID | LN00237894 |
| InChI | InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) |
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分类
- Heterocycles
- Inhibitors
- Sulfur & Selenium Compounds
- {SNA} A to C, Bioactive Small Molecule Alphabetical Index, Carbonic anhydrase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, M, 生化试剂, 生物活性小分子, 细胞生物学, 酶、抑制剂和底物
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Methazolamide is a carbonic anhydrase inhibitor. Methazolamide is used in the treatment of glaucoma.
相关文献及参考
- [2]. Abbate F, et al. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors. J Enzyme Inhib Med Chem. 2003;18(4):303-308.
- Iyer, G.R. et al.: J. Pharmac. Biomed. Anal., 16, 1021 (1998); Maren, T. H. et al.: Invest. Ophthamol. Vis. Sci., 16, 730 (1977);
- [1]. Yang F, et al. HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese. Pharmacogenomics J. 2016;16(1):83-87.
- [1]. Yang F, et al. HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese. Pharmacogenomics J. 2016;16(1):83-87.
- [2]. Abbate F, et al. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H332 Harmful if inhaled 吸入有害
- H351 Suspected of causing cancer 怀疑致癌
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- S22 Do not breathe dust 不要吸入粉尘；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,819,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2420 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,351,1975
其他信息
- MOL 文件:554-57-4.mol
- Sigma Aldrich:554-57-4(sigmaaldrich)
- 用途一:利尿药。
