Poly(vinylpyrrolidone)-Iodine complex 聚维酮碘
CAS 25655-41-8 MFCD00084483
化学结构图
SMILES: CCC(C)N1CCCC1=O
化学属性
| Mol. Weight | 0 |
|---|---|
| Mol. Formula | N/A |
| Melting Point | 300 |
| TSCA | Yes |
别名和识别编码
| CAS Number | 25655-41-8 |
|---|---|
| Chemical Name | Poly(vinylpyrrolidone)-Iodine complex |
| Synonym | 1-Vinyl-2-pyrrolidinone polymer, compd. with iodine 2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine Betadine Betaisodona Betaseptic Braunosan H Disadine DP Isodine PVP-I PVP-I Povadyne® antiseptic Poly(vinylpyrrolidone)–Iodine complex Povadyne® antiseptic |
| MDL Number | MFCD00084483 |
| PubChem Substance ID | 24899316 |
| Merck Number | 14,7698 |
| Chemical Name Translation | 聚维酮碘 |
| LabNetwork Molecule ID | LN01871797 |
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分类
- Pharmaceuticals
- {SNA} Antibiotics A to Z, Antibiotics N-S, Hydrophilic Polymers, Poly(vinylpyrrolidinone) (PVP)-Iodine Complex, Poly(vinylpyrrolidone) (PVP) and Copolymers, Polymer Science, Polymers, 抗生素, 材料科学, 生化试剂
- Heterocycles
- Intermediates & Fine Chemicals
- {SNA} Antibiotics, Antibiotics A to Z,
产品应用
- Topical anti-infective
相关文献及参考
- Kim, S., et al.: Food Sci., Biotechnol., 17, 971 (2008),
- Mary, G., et al.: Chem. Pharm. Bull., 56, 888 (2008),
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,788,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Human DOSE/DURATION : 3400 mg/kg/24H TOXIC EFFECTS : Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 240,249,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 480 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other tha
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 640 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,788,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,788,1982
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 5000 ppm REFERENCE : APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) Volume(issue)/page/year: 19,A106,1980
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 1 uL/disc REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 64,1235,1975
TYPE OF TEST : DNA damage TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 200 ppm REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 1,977,1976
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 5000 ppm REFERENCE : APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) Volume(issue)/page/year: 19,A106,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 11600 mg/kg
SEX/DURATION : female 15-22 day(s) after conception
lactating female 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 22,4663,1988TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 1450 mg/kg
SEX/DURATION : female 15-22 day(s) after conception
lactating female 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - physical
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 22,4663,1988TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 11600 mg/kg
SEX/DURATION : female 15-22 day(s) after conception
lactating female 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - other postnatal measures or eff