Enduracidin

CAS 11115-82-5 MFCD00131018

化学结构图

11115-82-5
SMILES: C[C@@H]1NC(=O)[C@@H](C[C@H]2CNC(N)=N2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](C[C@H]2CNC(N)=N2)NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CC(O)=O)NC(=O)/C=C\C=C\CCCCC%91C)[C@H](C)OC(=O)[C@H](NC1=O)C1C=CC(O)=CC=1)C1C=CC(O)=CC=1)[C@H](C)O)C1C=CC(O)=CC=1)C1C=CC(O)=CC=1)[C@@H](C)O)C1C=CC(O)=CC=1)C1=CC(Cl)=C(O)C(Cl)=C1.[*]%91 |&1:1,5,7,20,24,30,34,36,45,56,60,64,68,72,80,84,88,106,111,129,146|

化学属性

Mol. Weight2,355.3
Mol. FormulaC107H138Cl2N26O31 (for

别名和识别编码

CAS Number11115-82-5
Chemical NameEnduracidin
Synonym 恩拉霉素 Enradin Enramycin
MDL NumberMFCD00131018
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分类

  • Aromatics
  • Heterocycles
  • Peptides
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Enduracidin is a fermentation-derived cyclodepsipeptide antibiotic produced by Streptomyces fungicidicus. Enduracidin consists of two components: Enduracidin A and Enduracidin B. Enduracidin is used

相关文献及参考

  • Komatsuzawa, H. et al.: J. Antimicrob. Chemother., 33, 1155 (1994); Tanayama, S. et al.: J. Antibiot., 21, 313 (1968); Goto, S. et al.: J. Antibiot., 21, 119 (1968);

安全信息

WGK Germany2
RTECSJZ4107000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TDKNAF Takeda Kenkyusho Nempo.  Annual Report of the Takeda Research
   Laboratories.  (Osaka, Japan) V.1-28, 1936-69.  For publisher information,
   see TAKHAA.  Volume(issue)/page/year: 28,76,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TDKNAF Takeda Kenkyusho Nempo.  Annual Report of the Takeda Research
   Laboratories.  (Osaka, Japan) V.1-28, 1936-69.  For publisher information,
   see TAKHAA.  Volume(issue)/page/year: 28,76,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 66600 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TDKNAF Takeda Kenkyusho Nempo.  Annual Report of the Takeda Research
   Laboratories.  (Osaka, Japan) V.1-28, 1936-69.  For publisher information,
   see TAKHAA.  Volume(issue)/page/year: 28,76,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 92 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TDKNAF Takeda Kenkyusho Nempo.  Annual Report of the Takeda Research
   Laboratories.  (Osaka, Japan) V.1-28, 1936-69.  For publisher infor

系列性分类


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