(2S,3S)-3-(((S)-1-(Isopentylamino)-4-Methyl-1-Oxopentan-2-Yl)Carbamoyl)Oxirane-2-Carboxylic Acid (2S,3S)-3-(((S)-1-(异戊基氨基)-4-甲基-1-氧代戊烷-2-基)氨甲酰)环氧乙烷-2-羧酸
CAS 76684-89-4 MFCD00132882
化学结构图
SMILES: CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCC(C)C
化学属性
| Mol. Formula | C15H26N2O5 |
|---|---|
| Mol. Weight | 314.38 |
别名和识别编码
| Chemical Name | (2S,3S)-3-(((S)-1-(Isopentylamino)-4-Methyl-1-Oxopentan-2-Yl)Carbamoyl)Oxirane-2-Carboxylic Acid |
|---|---|
| Synonym | (+)-(2S,3S)-3-((S)-3-Methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylic acid (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane E 64C E-64c EP 475 EP 475 (Enzyme inhibitor) |
| MDL Number | MFCD00132882 |
| PubChem Substance ID | 24894369 |
| CAS Number | 76684-89-4 |
| Beilstein Registry Number | 6688621 |
| Chemical Name Translation | (2S,3S)-3-(((S)-1-(异戊基氨基)-4-甲基-1-氧代戊烷-2-基)氨甲酰)环氧乙烷-2-羧酸 |
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分类
- {SNA} A to C, Apoptosis Enzymes, Application Index, Bioactive Small Molecules, Biochemicals and Reagents,
- {SNA} A to C, Apoptosis Enzymes, Application Index, Calpain, Calpain II, Calpain II Inhibitors, Calpain Inhibitors, Cell Signaling Enzymes, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, General Inhibitors, Peptides and Proteins, Peptides for Cell Biology, Protease Inhibitor Specificity Index, Protease Inhibitors, Proteasome, Calpain and Lysosomal Proteases, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
相关文献及参考
- [2]. Toda G, et al. Calcium-activated neutral protease inhibitor (E-64c) and reperfusion for experimental myocardial infarction. Jpn Heart J. 1989 May;30(3):375-86.
- [3]. Radzey H, et al. E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors. ChemMedChem. 2013 Aug;8(8):1314-21.
- [4]. Ji Yeun Kim, et al. Safe, High-Throughput Screening of Natural Compounds of MERS-CoV Entry Inhibitors Using a Pseudovirus Expressing MERS-CoV Spike Protein. Int J Antimicrob Agents. 2018 Nov;52(5):730-732.
- [1]. Khan MS, et al. Design, synthesis, evaluation and thermodynamics of 1-substituted pyridylimidazo[1,5-a]pyridine derivatives as cysteine protease inhibitors. PLoS One. 2013 Aug 5;8(8):e69982.
- [1]. Khan MS, et al. Design, synthesis, evaluation and thermodynamics of 1-substituted pyridylimidazo[1,5-a]pyridine derivatives as cysteine protease inhibitors. PLoS One. 2013 Aug 5;8(8):e69982.
- [2]. Toda G, et al. Calcium
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2140 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,736,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,736,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2400 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2400 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, T
