4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride 4-(2-氨乙基)苯磺酰氟盐酸盐

CAS 30827-99-7 MFCD00132962

化学结构图

30827-99-7
SMILES: Cl.NCCC1=CC=C(C=C1)S(=O)(=O)F

化学属性

Mol. FormulaC8H11ClFNO2S
Mol. Weight240
Melting Point183
TSCANo
Density0.729
Stability对湿度敏感

别名和识别编码

Chemical Name4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
CAS Number30827-99-7
Alfabeta NameAMINOETHYLBENZENESULFONYLFLUORIDEHYDROCHLORIDE 42()--
MDL NumberMFCD00132962
Synonym
PubChem Substance ID87561163
Beilstein Registry Number7604627
Reaxys-RN7604627
EC Number250-023-7
Chemical Name Translation4-(2-氨乙基)苯磺酰氟盐酸盐
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分类

  • {SNA} A to C,
  • A to C, A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Cell Biology, Chymotrypsin, α-, Chymotrypsin, alpha-, Coagulation Proteins and Reagents, Core Bioreagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inhibitors, Native Protein Sample Preparation, P to Q, Plasma & Blood Proteins, Plasmin, Protease Inhibitor Specificity Index, Protease Inhibitors, Proteins and Derivatives, Proteomics, R to Z, Research Essentials,
  • {SNA} Aliphatics,
  • {SNA} Addit

产品应用

  • 推荐使用浓度为0.1-1 mM.
  • 不可逆的丝氨酸蛋白酶抑制剂,抑制胰蛋白酶,糜蛋白酶,纤溶酶,凝血酶及激肽释放酶. 可溶于水,其pH7的水溶液在4oC可保持稳定1-2个月。

相关文献及参考

  • [2]. Nakabo Y, et al. Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. J Leukoc Biol. 1996 Sep;60(3):328-36.
  • [3]. Buitrago-Rey R, et al. Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis. J Antimicrob Chemother.
  • [4]. Jiang YH, et al. Serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro. Contraception. 2011 Dec;84(6):642-8.
  • Irreverersible serine protease inhibitor: Thromb. Res., 2, 343 (1973); Acta Biol. Med. Ger., 39, 355 (1980).
  • Markwardt, F., et al. Thromb. Res. 2 , 343, (1973)
  • Mintz, G.R. BioPharm. 6 , 34, (1993)
  • [1]. Citron M, et al. Inhibition of amyloid

安全信息

GHS Symbol
WGK Germany3
Hazard Codes C
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Precautionary statements
  • P303+P361+P353+P310+P363
  • P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P405 Store locked up. 上锁保管。
  • P304+P340
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P304+P340+P310
  • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
  • P305+P351+P338+P310
  • P301+P330+P331+P310
Signal word
Storage condition Moisture Sensitive <;0 <0°C 贮存温度-20℃
UN Number 3261
Safety Statements
Risk Statements
Packing GroupII
Hazard Class8

其他信息

  • 熔点：181-185℃

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. P - Alphabetic
  5. PA - PEN - P
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Organic Covalent Modifiers - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Analytical Enzymes - Enzymes, Inhibitors, and Substrates
  5. Trypsin - Analytical Enzymes
  6. Trypsin Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Dry Powder Media
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Plasma & Blood Proteins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Analytical Enzymes
  5. Trypsin
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Thermolysin
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Topoisomerase II
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Protease Inhibitors
  6. Protease Inhibitor Specificity Index
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Proteolytic Enzymes and Substrates
  5. Protease Inhibitors
  6. Protease Inhibitor Specificity Index
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Signal Transduction Research Tools
  5. Protease Inhibitors
  6. Protease Inhibitor Specificity Index
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Cholinesterase, butyryl
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Phospholipase D
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteomics
  4. Native Protein Sample Preparation
  5. Cell Lysis and Protein Extraction Reagents
  6. Protein Sample Clarification
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Metalloproteinase Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Proteolytic Enzymes and Substrates
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Metalloproteinase Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Proteolytic Enzymes and Substrates
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Signal Transduction Research Tools
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Metalloproteinase Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Signal Transduction Research Tools
  5. Protease Inhibitors
  6. Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  7. Serine Protease Inhibitors
  1. Medical Research Areas
  2. Metabolism
  3. Thrombin  (凝血酶)

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