CAS 5053-08-7 MFCD00133315-C15H21Cln2O2 盐酸芬司必利 TAO{mole}

C15H21Cln2O2 盐酸芬司必利

CAS 5053-08-7 MFCD00133315

化学结构图

SMILES: Cl.O=C1NCC2(CCN(CCc3ccccc3)CC2)O1

化学属性

Mol. Formula	C15H20N2O2·HCl
Mol. Weight	296.80

别名和识别编码

Chemical Name	C15H21Cln2O2
CAS Number	5053-08-7
Synonym	3612 S 3612-S 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro(4.5)decan-2-one hydrochloride 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one Hydrochloride 8-(2-苯乙基)-1-氧杂-3,8-二氮杂螺[4.5]癸烷-2-酮盐酸盐 8-N-Fenetil-1-oxa-2-oxo-3,8-diazaspiro-(4,5)-decano cloridrato Chlorhydrate de phenethyl-8-oxa-1-diaza-3,8-spiro(4,5)decanone-2 Decaspir Decaspiride Decaspiride hydrochloride Erespal Espiran Fenspiride Fenspiride hydrochloride Fluiden JP 428 JP 428 hydrochloride NAT 333 NAT-333 hydrochloride NDR 5998A NDR-5998A hydrochloride Phenethyl-8-oxa-1-diaza-3,8-spiro(4,5)decanone-2-hydrochloride Pneumorel Respiride Tegencia Tegencia hydrochloride Viarespan Viarespan hydrochloride decaspiride {PubChem
MDL Number	MFCD00133315
EC Number	225-752-9
PubChem Substance ID	68626
Chemical Name Translation	盐酸芬司必利
Wiswesser Line Notation	T6N CXTJ A2R& C-& DT5MVOX EHJ &GH
LabNetwork Molecule ID	LN01304216
Reaxys-RN	9017699
Merck Number	3999
InChI	InChI=1S/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H

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分类

{SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites, F, FA - FL, Forensic and Veterinary Standards, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Neat Compounds, 细胞信号转导和神经科学, 细胞生物学
{SNA} Additional Standards, Analytical Standards, Antiasthmatic Drug Standards, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Neat Compounds,

产品应用

Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist a

安全信息

Hazard Codes Xn

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312
P301+P312+P330
P302+P352
P304+P312
P304+P340
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P501 Dispose of contents/container to..… 处理内容物/容器.....

WGK Germany3

Hazard statements

H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害
H332 Harmful if inhaled 吸入有害

Signal word Warning

RTECSRO0375000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 437 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depre

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 193,111,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 193,111,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Behavioral - aggression
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,343,1978

TYPE OF TEST

Storage condition 0-10°C