Glp-1(7-36) Amide 胰高血糖素样肽1(7-36)酰胺
CAS 107444-51-9 MFCD00133373
化学结构图
SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CNC=N1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2C=CC=CC1=2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
化学属性
| Mol. Formula | C149H226N40O45 |
|---|---|
| Mol. Weight | 3297.63 |
别名和识别编码
| Chemical Name | Glp-1(7-36) Amide |
|---|---|
| Synonym | Preproglucagon 78-107 Amide |
| MDL Number | MFCD00133373 |
| CAS Number | 107444-51-9 |
| PubChem Substance ID | 329799974 |
| Chemical Name Translation | 胰高血糖素样肽1(7-36)酰胺 |
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分类
- Cell Biology, Cell Signaling and Neuroscience, Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, GLP-1 Receptor Ligands, Gastrointestinal Peptides, Glucagon, Glucagon and Glucagon-Like Peptides, Glucagon-Like Pepti
- {SNA} Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, GLP-1 Receptor Ligands, Gastrointestinal Peptides, Glucagon, Glucagon and Glucagon-Like Peptides, Glucagon-Like Peptides, Hormones, Obesity Peptides, Other Protein/Peptide Hormones, Peptides and Proteins, Peptides for Cell Biology, 细胞信号转导和神经科学, 细胞生物学,
相关文献及参考
- [2]. Mentlein R, et al. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem. 1993 Jun 15;214(3):829-35.
- [3]. Nauck MA, et al. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1993 Aug;36(8):741-4.
- [4]. Hansen L, et al. Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology. 1999 Nov;140(11):5356-63.
- Bell, G., et al., Exon duplication and divergence in the human preproglucagon gene. Nature 304 , 368-371 摘要
- [1]. Kreymann
- [1]. Kreymann B, et al. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet. 1987 Dec 5;2(8571):1300-4.
