Natamycin (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-(((2R,3S,4S,5S,6R)-4-氨基-3,5-二羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-1,3,26-三羟基-12-甲基-10-氧代-6,11,28-三氧三环[22.3.1.05,7 ] 二十八烷-8,14,16,18,20-戊烯-25-羧酸
CAS 7681-93-8 MFCD00135085
化学结构图
SMILES: C[C@@H]1C/C=C/C=C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@H]2O[C@](O)(C[C@@H](O)C[C@H]3O[C@@H]3/C=C/C(=O)O1)C[C@H](O)[C@H]2C(=O)O
化学属性
| Mol. Formula | C33H47NO13 |
|---|---|
| Mol. Weight | 666 |
| Density | 1.0 g/mL at 20 °C(lit.) |
别名和识别编码
| Chemical Name | Natamycin |
|---|---|
| CAS Number | 7681-93-8 |
| Synonym | Antibiotic A 5283 CL 12,625 Delvocid Delvolan Delvopos Mycophyt Myprozine Natacyn Natamycin Pimafucin Pimaricin Pimarizin Synogil Tennecetin 匹马霉素 游霉素 那他霉素 |
| MDL Number | MFCD00135085 |
| PubChem Substance ID | 5284447 |
| EC Number | 231-683-5 |
| Beilstein Registry Number | 1614878 |
| Chemical Name Translation | (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-(((2R,3S,4S,5S,6R)-4-氨基-3,5-二羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-1,3,26-三羟基-12-甲基-10-氧代-6,11,28-三氧三环[22.3.1.05,7 ] 二十八烷-8,14,16,18,20-戊烯-25-羧酸 |
| Wiswesser Line Notation | T3-25- BO DV SOV IU KU MU OU UUTJ EVQ FQ R1 C&YQ1QC&Q HO- BT5OTJ CQ DZ EYQ1 |
| LabNetwork Molecule ID | LN01327049 |
| InChI | InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Biochemicals and Reagents, Chemical Structure Class, Chromatography, Environmental Standards, Fungicides, Interferes with Cell Membrane Permeability (Ionophores), Macrolides, Mechanism of Action, Pesticides, Pesticides & Metabolites, Spectrum of Activity
- {SNA} Antibiotics A to Z, Antibiotics N-S, Antifungal, Interferes with Cell Membrane Permeability (Ionophores), Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
- {SNA} A
产品应用
- 一种抗真菌的多烯类抗生素，靠特异性地结合麦角甾醇，抑制真菌生长。 不像制霉菌素和菲律宾霉素, 纳他霉素不改变细胞膜的通透性。
相关文献及参考
- [2]. Yvonne Maria te Welscher, et al. Polyene antibiotic that inhibits membrane transport proteins. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11156-9.
- Brik, H., et al.: Anal. Profiles Drug Subs. Excip., 23, 399 (1994),
- Levinskas, G.J., et al.: Toxicol. Appl. Pharmacol., 8, 97 (1966),
- Merck: 14,6427
- Pandey, R.C., et al.: J. Antibiot., 29, 1035 (1976),
- [1]. Wu H, et al. SlnM gene overexpression with different promoters on natamycin production in Streptomyces lydicus A02. J Ind Microbiol Biotechnol. 2014 Jan;41(1):163-72.
- [1]. Wu H, et al. SlnM gene overexpression with different promoters on natamycin production in Streptomyces lydicus A02. J Ind Microbiol Biotechnol. 2014 Jan;41(1):163-72.
- [2]. Yvonne Maria te Welscher, et al. Polyene antibiotic that inhibits membrane transport proteins. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11156-9.
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150,
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 5,878,1957/1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 190 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 128 mg
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands) V.1-19, 1961-81. For publisher information, see IJCREE. Volume(issue)/page/year: 8,1274,1968
TYPE OF
TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Mold - Aspergillus nidulans DOSE/DURATION : 30 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 79,169,1980
其他信息
- 几乎无臭无味，可含3mol的水，几乎不溶于水，高级醇、醚、酯，微溶于甲醇，溶于冰醋酸和二甲苯亚 砜。对氧化剂和紫外线较为敏感。
